Journal Article

DKFZ-2020-00178

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.

Delacher, M. (First author)DKFZ* ; Imbusch, C. D. (First author)DKFZ* ; Hotz-Wagenblatt, A.DKFZ* ; Mallm, J.-P.DKFZ* ; Bauer, K.DKFZ* ; Simon, M.DKFZ* ; Riegel, D. ; Rendeiro, A. F. ; Bittner, S. ; Sanderink, L. ; Pant, A. ; Schmidleithner, L. ; Braband, K.DKFZ* ; Echtenachter, B. ; Fischer, A. ; Giunchiglia, V. ; Hoffmann, P. ; Edinger, M. ; Bock, C. ; Rehli, M. ; Brors, B.DKFZ* ; Schmidl, C. ; Feuerer, M. (Last author)DKFZ*

2020
Elsevier New York, NY

This record in other databases:  

Please use a persistent id in citations: doi:10.1016/j.immuni.2019.12.002

Abstract: Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice and single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of interleukin 33 (IL-33) receptor ST2-expressing nonlymphoid tissue Treg cells, which resided in the spleen and lymph nodes. Global chromatin profiling of nonlymphoid tissue Treg cells and the two precursor stages revealed a stepwise acquisition of chromatin accessibility and reprogramming toward the nonlymphoid-tissue Treg cell phenotype. Mechanistically, we identified and validated the transcription factor Batf as the driver of the molecular tissue program in the precursors. Understanding this tissue development program will help to harness regenerative properties of tissue Treg cells for therapy.

Note: 2020 Feb 18;52(2):295-312.e11#EA:D100#EA:B330#LA:D100#

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Contributing Institute(s):

1. Immuntoleranz (D100)
2. Angewandte Bioinformatik (B330)
3. W610 Omics IT and Data Management (W610)
4. W192 scOpen Lab (W192)
5. B066 Chromatin-Netzwerke (B066)
6. DKTK HD zentral (HD01)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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