TY  - JOUR
AU  - Delacher, Michael
AU  - Imbusch, Charles D
AU  - Hotz-Wagenblatt, Agnes
AU  - Mallm, Jan-Philipp
AU  - Bauer, Katharina
AU  - Simon, Malte
AU  - Riegel, Dania
AU  - Rendeiro, André F
AU  - Bittner, Sebastian
AU  - Sanderink, Lieke
AU  - Pant, Asmita
AU  - Schmidleithner, Lisa
AU  - Braband, Kathrin
AU  - Echtenachter, Bernd
AU  - Fischer, Alexander
AU  - Giunchiglia, Valentina
AU  - Hoffmann, Petra
AU  - Edinger, Matthias
AU  - Bock, Christoph
AU  - Rehli, Michael
AU  - Brors, Benedikt
AU  - Schmidl, Christian
AU  - Feuerer, Markus
TI  - Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.
JO  - Immunity
VL  - 52
IS  - 2
SN  - 1074-7613
CY  - New York, NY
PB  - Elsevier
M1  - DKFZ-2020-00178
SP  - 295-312.e11
PY  - 2020
N1  - 2020 Feb 18;52(2):295-312.e11#EA:D100#EA:B330#LA:D100#
AB  - Specialized regulatory T (Treg) cells accumulate and perform homeostatic and regenerative functions in nonlymphoid tissues. Whether common precursors for nonlymphoid-tissue Treg cells exist and how they differentiate remain elusive. Using transcription factor nuclear factor, interleukin 3 regulated (Nfil3) reporter mice and single-cell RNA-sequencing (scRNA-seq), we identified two precursor stages of interleukin 33 (IL-33) receptor ST2-expressing nonlymphoid tissue Treg cells, which resided in the spleen and lymph nodes. Global chromatin profiling of nonlymphoid tissue Treg cells and the two precursor stages revealed a stepwise acquisition of chromatin accessibility and reprogramming toward the nonlymphoid-tissue Treg cell phenotype. Mechanistically, we identified and validated the transcription factor Batf as the driver of the molecular tissue program in the precursors. Understanding this tissue development program will help to harness regenerative properties of tissue Treg cells for therapy.
LB  - PUB:(DE-HGF)16
C6  - pmid:31924477
DO  - DOI:10.1016/j.immuni.2019.12.002
UR  - https://inrepo02.dkfz.de/record/153096
ER  -