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@ARTICLE{Delacher:153096,
      author       = {M. Delacher$^*$ and C. D. Imbusch$^*$ and A.
                      Hotz-Wagenblatt$^*$ and J.-P. Mallm$^*$ and K. Bauer$^*$ and
                      M. Simon$^*$ and D. Riegel and A. F. Rendeiro and S. Bittner
                      and L. Sanderink and A. Pant and L. Schmidleithner and K.
                      Braband$^*$ and B. Echtenachter and A. Fischer and V.
                      Giunchiglia and P. Hoffmann and M. Edinger and C. Bock and
                      M. Rehli and B. Brors$^*$ and C. Schmidl and M. Feuerer$^*$},
      title        = {{P}recursors for {N}onlymphoid-{T}issue {T}reg {C}ells
                      {R}eside in {S}econdary {L}ymphoid {O}rgans and {A}re
                      {P}rogrammed by the {T}ranscription {F}actor {BATF}.},
      journal      = {Immunity},
      volume       = {52},
      number       = {2},
      issn         = {1074-7613},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-00178},
      pages        = {295-312.e11},
      year         = {2020},
      note         = {2020 Feb 18;52(2):295-312.e11#EA:D100#EA:B330#LA:D100#},
      abstract     = {Specialized regulatory T (Treg) cells accumulate
                      and perform homeostatic and regenerative functions in
                      nonlymphoid tissues. Whether common precursors for
                      nonlymphoid-tissue Treg cells exist and how they
                      differentiate remain elusive. Using transcription factor
                      nuclear factor, interleukin 3 regulated (Nfil3) reporter
                      mice and single-cell RNA-sequencing (scRNA-seq), we
                      identified two precursor stages of interleukin 33 (IL-33)
                      receptor ST2-expressing nonlymphoid tissue Treg cells, which
                      resided in the spleen and lymph nodes. Global chromatin
                      profiling of nonlymphoid tissue Treg cells and the two
                      precursor stages revealed a stepwise acquisition of
                      chromatin accessibility and reprogramming toward the
                      nonlymphoid-tissue Treg cell phenotype. Mechanistically, we
                      identified and validated the transcription factor Batf as
                      the driver of the molecular tissue program in the
                      precursors. Understanding this tissue development program
                      will help to harness regenerative properties of tissue Treg
                      cells for therapy.},
      cin          = {D100 / B330 / W610 / W192 / B066 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)D100-20160331 / I:(DE-He78)B330-20160331 /
                      I:(DE-He78)W610-20160331 / I:(DE-He78)W192-20160331 /
                      I:(DE-He78)B066-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31924477},
      doi          = {10.1016/j.immuni.2019.12.002},
      url          = {https://inrepo02.dkfz.de/record/153096},
}