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@ARTICLE{Link:153107,
      author       = {C. Link$^*$ and F. Bujupi$^*$ and P. H. Krammer$^*$ and H.
                      Weyd$^*$},
      title        = {{A}nnexin-coated particles induce antigen-specific
                      immunosuppression.},
      journal      = {Autoimmunity},
      volume       = {53},
      number       = {2},
      issn         = {1607-842X},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {DKFZ-2020-00189},
      pages        = {86-94},
      year         = {2020},
      note         = {#EA:D030#LA:D030#2020 Mar;53(2):86-94},
      abstract     = {Apoptotic cells mediate the development of tolerogenic
                      dendritic cells (DC) and thus facilitate induction and
                      maintenance of peripheral tolerance. Following the
                      identification of the evolutionary conserved annexin core
                      domain (Anx) as a specific signal on apoptotic cells which
                      antagonises Toll-like receptor (TLR) signalling, we examined
                      whether the tolerogenic capacity of Anx can be exploited to
                      downregulate antigen-specific immune responses. The
                      treatment of bone marrow-derived dendritic cells (BMDC) with
                      particles harbouring Anx as well as the model antigen
                      ovalbumin (OVA) attenuated the response of OVA-specific
                      OT-II T cells. The co-culture of Anx-particle-treated DC and
                      T cells resulted in an anergy-like phenotype characterized
                      by reduced proliferation and cytokine secretion. Here we
                      demonstrate that the anti-inflammatory effects of Anx which
                      are mediated through DC can be used as a tool to generate a
                      particle-based antigen delivery system that promotes
                      antigen-specific immunosuppression. Such Anx-particles may
                      be a new therapeutic approach for the treatment of
                      autoimmune diseases.},
      cin          = {D030},
      ddc          = {610},
      cid          = {I:(DE-He78)D030-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31933381},
      doi          = {10.1080/08916934.2019.1710134},
      url          = {https://inrepo02.dkfz.de/record/153107},
}