Journal Article

DKFZ-2020-00189

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Annexin-coated particles induce antigen-specific immunosuppression.

Link, C. (First author)DKFZ* ; Bujupi, F.DKFZ* ; Krammer, P. H.DKFZ* ; Weyd, H. (Last author)DKFZ*

2020
Taylor & Francis Group Abingdon

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Please use a persistent id in citations: doi:10.1080/08916934.2019.1710134

Abstract: Apoptotic cells mediate the development of tolerogenic dendritic cells (DC) and thus facilitate induction and maintenance of peripheral tolerance. Following the identification of the evolutionary conserved annexin core domain (Anx) as a specific signal on apoptotic cells which antagonises Toll-like receptor (TLR) signalling, we examined whether the tolerogenic capacity of Anx can be exploited to downregulate antigen-specific immune responses. The treatment of bone marrow-derived dendritic cells (BMDC) with particles harbouring Anx as well as the model antigen ovalbumin (OVA) attenuated the response of OVA-specific OT-II T cells. The co-culture of Anx-particle-treated DC and T cells resulted in an anergy-like phenotype characterized by reduced proliferation and cytokine secretion. Here we demonstrate that the anti-inflammatory effects of Anx which are mediated through DC can be used as a tool to generate a particle-based antigen delivery system that promotes antigen-specific immunosuppression. Such Anx-particles may be a new therapeutic approach for the treatment of autoimmune diseases.

Note: #EA:D030#LA:D030#2020 Mar;53(2):86-94

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Contributing Institute(s):

1. D030 Immungenetik (D030)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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