%0 Journal Article
%A Jakszyn, P.
%A Cayssials, V.
%A Buckland, G.
%A Perez-Cornago, A.
%A Weiderpass, E.
%A Boeing, H.
%A Bergmann, M. M.
%A Vulcan, A.
%A Ohlsson, B.
%A Masala, G.
%A Cross, A. J.
%A Riboli, E.
%A Ricceri, F.
%A Dahm, C.
%A Nyvang, D.
%A Katzke, V. A.
%A Kühns, T.
%A Kyrø, C.
%A Tjønneland, A.
%A Ward, H. A.
%A Tsilidis, K. K.
%A Skeie, G.
%A Sieri, S.
%A Sanchez, M. J.
%A Huerta, J. M.
%A Amiano, P.
%A Lasheras, C.
%A Ardanaz, E.
%A Mahamat-Saleh, Y.
%A Boutron-Ruault, M. C.
%A Carbonnel, F.
%A Panico, S.
%A Peppa, E.
%A Trichopoulou, A.
%A Karakatsani, A.
%A Tumino, R.
%A Vermeulen, R.
%A Jenab, M.
%A Gunter, M.
%A Agudo, A.
%T Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
%J International journal of cancer
%V 147
%N 4
%@ 1097-0215
%C Bognor Regis
%I Wiley-Liss
%M DKFZ-2020-00219
%P 1027-1039
%D 2020
%Z 2020 Aug 15;147(4):1027-1039
%X Pro-inflammatory diets are associated with risk of developing colorectal cancer (CRC), however inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute towards a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumours). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More pro- inflammatory diets were related to a higher CRC risk, particularly for colon cancer; Hazar Ratio (HR) for highest versus lowest ISD quartile was 1.15 (95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:31945199
%R 10.1002/ijc.32870
%U https://inrepo02.dkfz.de/record/153166