Journal Article

DKFZ-2020-00219

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Inflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

Jakszyn, P. ; Cayssials, V. ; Buckland, G. ; Perez-Cornago, A. ; Weiderpass, E. ; Boeing, H. ; Bergmann, M. M. ; Vulcan, A. ; Ohlsson, B. ; Masala, G. ; Cross, A. J. ; Riboli, E. ; Ricceri, F. ; Dahm, C. ; Nyvang, D. ; Katzke, V. A.DKFZ* ; Kühns, T.DKFZ* ; Kyrø, C. ; Tjønneland, A. ; Ward, H. A. ; Tsilidis, K. K. ; Skeie, G. ; Sieri, S. ; Sanchez, M. J. ; Huerta, J. M. ; Amiano, P. ; Lasheras, C. ; Ardanaz, E. ; Mahamat-Saleh, Y. ; Boutron-Ruault, M. C. ; Carbonnel, F. ; Panico, S. ; Peppa, E. ; Trichopoulou, A. ; Karakatsani, A. ; Tumino, R. ; Vermeulen, R. ; Jenab, M. ; Gunter, M. ; Agudo, A.

2020
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.32870

Abstract: Pro-inflammatory diets are associated with risk of developing colorectal cancer (CRC), however inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute towards a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumours). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More pro- inflammatory diets were related to a higher CRC risk, particularly for colon cancer; Hazar Ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval (CI) 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS were 1.62 (95% CI 1.31- 2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. This study shows that more pro-inflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men. This article is protected by copyright. All rights reserved.

Note: 2020 Aug 15;147(4):1027-1039

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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