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000153166 1001_ $$00000-0003-0672-8847$$aJakszyn, P.$$b0
000153166 245__ $$aInflammatory potential of the diet and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
000153166 260__ $$aBognor Regis$$bWiley-Liss$$c2020
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000153166 500__ $$a2020 Aug 15;147(4):1027-1039
000153166 520__ $$aPro-inflammatory diets are associated with risk of developing colorectal cancer (CRC), however inconsistencies exist in subsite- and sex-specific associations. The relationship between CRC and combined lifestyle-related factors that contribute towards a low-grade inflammatory profile has not yet been explored. We examined the association between the dietary inflammatory potential and an inflammatory profile and CRC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. This cohort included 476,160 participants followed-up of 14 years and 5,991 incident CRC cases (3,897 colon and 2,094 rectal tumours). Dietary inflammatory potential was estimated using an Inflammatory Score of the Diet (ISD). An Inflammatory Profile Score (IPS) was constructed, incorporating the ISD, physical activity level and abdominal obesity. The associations between the ISD and CRC and IPS and CRC were assessed using multivariable regression models. More pro- inflammatory diets were related to a higher CRC risk, particularly for colon cancer; Hazar Ratio (HR) for highest versus lowest ISD quartile was 1.15 (95% confidence interval (CI) 1.04-1.27) for CRC, 1.24 (95% CI 1.09-1.41) for colon cancer and 0.99 (95% CI 0.83-1.17) for rectal cancer. Associations were more pronounced in men and not significant in women. The IPS was associated with CRC risk, particularly colon cancer among men; HRs for the highest versus lowest IPS were 1.62 (95% CI 1.31- 2.01) for colon cancer overall and 2.11 (95% CI 1.50-2.97) for colon cancer in men. This study shows that more pro-inflammatory diets and a more inflammatory profile are associated with higher risk of CRC, principally colon cancer and in men. This article is protected by copyright. All rights reserved.
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000153166 7001_ $$aCayssials, V.$$b1
000153166 7001_ $$aBuckland, G.$$b2
000153166 7001_ $$aPerez-Cornago, A.$$b3
000153166 7001_ $$00000-0003-2237-0128$$aWeiderpass, E.$$b4
000153166 7001_ $$aBoeing, H.$$b5
000153166 7001_ $$aBergmann, M. M.$$b6
000153166 7001_ $$aVulcan, A.$$b7
000153166 7001_ $$aOhlsson, B.$$b8
000153166 7001_ $$aMasala, G.$$b9
000153166 7001_ $$aCross, A. J.$$b10
000153166 7001_ $$aRiboli, E.$$b11
000153166 7001_ $$00000-0001-8749-9737$$aRicceri, F.$$b12
000153166 7001_ $$aDahm, C.$$b13
000153166 7001_ $$aNyvang, D.$$b14
000153166 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, V. A.$$b15$$udkfz
000153166 7001_ $$0P:(DE-HGF)0$$aKühns, T.$$b16
000153166 7001_ $$00000-0002-9083-8960$$aKyrø, C.$$b17
000153166 7001_ $$aTjønneland, A.$$b18
000153166 7001_ $$00000-0002-2721-2404$$aWard, H. A.$$b19
000153166 7001_ $$00000-0002-8452-8472$$aTsilidis, K. K.$$b20
000153166 7001_ $$aSkeie, G.$$b21
000153166 7001_ $$00000-0001-5201-172X$$aSieri, S.$$b22
000153166 7001_ $$aSanchez, M. J.$$b23
000153166 7001_ $$aHuerta, J. M.$$b24
000153166 7001_ $$aAmiano, P.$$b25
000153166 7001_ $$aLasheras, C.$$b26
000153166 7001_ $$aArdanaz, E.$$b27
000153166 7001_ $$aMahamat-Saleh, Y.$$b28
000153166 7001_ $$00000-0002-5956-5693$$aBoutron-Ruault, M. C.$$b29
000153166 7001_ $$aCarbonnel, F.$$b30
000153166 7001_ $$aPanico, S.$$b31
000153166 7001_ $$aPeppa, E.$$b32
000153166 7001_ $$aTrichopoulou, A.$$b33
000153166 7001_ $$aKarakatsani, A.$$b34
000153166 7001_ $$aTumino, R.$$b35
000153166 7001_ $$aVermeulen, R.$$b36
000153166 7001_ $$aJenab, M.$$b37
000153166 7001_ $$aGunter, M.$$b38
000153166 7001_ $$aAgudo, A.$$b39
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