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@ARTICLE{Jakszyn:153166,
      author       = {P. Jakszyn and V. Cayssials and G. Buckland and A.
                      Perez-Cornago and E. Weiderpass and H. Boeing and M. M.
                      Bergmann and A. Vulcan and B. Ohlsson and G. Masala and A.
                      J. Cross and E. Riboli and F. Ricceri and C. Dahm and D.
                      Nyvang and V. A. Katzke$^*$ and T. Kühns$^*$ and C. Kyrø
                      and A. Tjønneland and H. A. Ward and K. K. Tsilidis and G.
                      Skeie and S. Sieri and M. J. Sanchez and J. M. Huerta and P.
                      Amiano and C. Lasheras and E. Ardanaz and Y. Mahamat-Saleh
                      and M. C. Boutron-Ruault and F. Carbonnel and S. Panico and
                      E. Peppa and A. Trichopoulou and A. Karakatsani and R.
                      Tumino and R. Vermeulen and M. Jenab and M. Gunter and A.
                      Agudo},
      title        = {{I}nflammatory potential of the diet and risk of colorectal
                      cancer in the {E}uropean {P}rospective {I}nvestigation into
                      {C}ancer and {N}utrition ({EPIC}) study.},
      journal      = {International journal of cancer},
      volume       = {147},
      number       = {4},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-00219},
      pages        = {1027-1039},
      year         = {2020},
      note         = {2020 Aug 15;147(4):1027-1039},
      abstract     = {Pro-inflammatory diets are associated with risk of
                      developing colorectal cancer (CRC), however inconsistencies
                      exist in subsite- and sex-specific associations. The
                      relationship between CRC and combined lifestyle-related
                      factors that contribute towards a low-grade inflammatory
                      profile has not yet been explored. We examined the
                      association between the dietary inflammatory potential and
                      an inflammatory profile and CRC risk in the European
                      Prospective Investigation into Cancer and Nutrition (EPIC)
                      study. This cohort included 476,160 participants followed-up
                      of 14 years and 5,991 incident CRC cases (3,897 colon and
                      2,094 rectal tumours). Dietary inflammatory potential was
                      estimated using an Inflammatory Score of the Diet (ISD). An
                      Inflammatory Profile Score (IPS) was constructed,
                      incorporating the ISD, physical activity level and abdominal
                      obesity. The associations between the ISD and CRC and IPS
                      and CRC were assessed using multivariable regression models.
                      More pro- inflammatory diets were related to a higher CRC
                      risk, particularly for colon cancer; Hazar Ratio (HR) for
                      highest versus lowest ISD quartile was 1.15 $(95\%$
                      confidence interval (CI) 1.04-1.27) for CRC, 1.24 $(95\%$ CI
                      1.09-1.41) for colon cancer and 0.99 $(95\%$ CI 0.83-1.17)
                      for rectal cancer. Associations were more pronounced in men
                      and not significant in women. The IPS was associated with
                      CRC risk, particularly colon cancer among men; HRs for the
                      highest versus lowest IPS were 1.62 $(95\%$ CI 1.31- 2.01)
                      for colon cancer overall and 2.11 $(95\%$ CI 1.50-2.97) for
                      colon cancer in men. This study shows that more
                      pro-inflammatory diets and a more inflammatory profile are
                      associated with higher risk of CRC, principally colon cancer
                      and in men. This article is protected by copyright. All
                      rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31945199},
      doi          = {10.1002/ijc.32870},
      url          = {https://inrepo02.dkfz.de/record/153166},
}