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000153590 1001_ $$0P:(DE-He78)74a6af8347ec5cbd4b77e562e10ca1f2$$aTurzanski-Fortner, Renée$$b0$$eFirst author$$udkfz
000153590 245__ $$aTheoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort.
000153590 260__ $$aBognor Regis$$bWiley-Liss$$c2020
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000153590 500__ $$a2020 Sep 1;147(5):1325-1333#EA:C020#LA:C020#
000153590 520__ $$aEndometrial cancer (EC) incidence rates vary ~10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low-risk countries can be explained by differences in these patterns. Predicted EC incidence rates were estimated over 10 years of follow-up for the cohort before and after modifying risk factor profiles. Risk factors considered were: body mass index (BMI, kg/m2 ), use of postmenopausal hormone therapy (HT) and oral contraceptives (OC) (potentially modifiable); and, parity, ages at first birth, menarche and menopause (environmentally conditioned, but not readily modifiable). Modeled alterations in BMI (to all ≤23 kg/m2 ) and HT use (to all non-HT users) profiles resulted in a 30% reduction in predicted EC incidence rates; individually, longer duration of OC use (to all ≥10 years) resulted in a 42.5% reduction. Modeled changes in not readily modifiable exposures (i.e., those not contributing to prevention potential) resulted in ≤24.6% reduction in predicted EC incidence. Women in the lowest decile of a risk score based on the evaluated exposures had risk similar to a low risk countries; however, this was driven by relatively long use of OCs (median = 23 years). Our findings support avoidance of overweight BMI and of HT use as prevention strategies for EC in a European population; OC use must be considered in the context of benefits and risks. This article is protected by copyright. All rights reserved.
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000153590 7001_ $$0P:(DE-He78)6519c85d61a3def7974665471b8a4f74$$aHüsing, Anika$$b1$$udkfz
000153590 7001_ $$aDossus, Laure$$b2
000153590 7001_ $$aTjønneland, Anne$$b3
000153590 7001_ $$aOvervad, Kim$$b4
000153590 7001_ $$aDahm, Christina C$$b5
000153590 7001_ $$aArveux, Patrick$$b6
000153590 7001_ $$aFournier, Agnès$$b7
000153590 7001_ $$00000-0002-4557-3772$$aKvaskoff, Marina$$b8
000153590 7001_ $$aSchulze, Matthias B$$b9
000153590 7001_ $$aBergmann, Manuela$$b10
000153590 7001_ $$aTrichopoulou, Antonia$$b11
000153590 7001_ $$aKarakatsani, Anna$$b12
000153590 7001_ $$00000-0003-1441-897X$$aLa Vecchia, Carlo$$b13
000153590 7001_ $$aMasala, Giovanna$$b14
000153590 7001_ $$aPala, Valeria$$b15
000153590 7001_ $$aMattiello, Amalia$$b16
000153590 7001_ $$aTumino, Rosario$$b17
000153590 7001_ $$00000-0001-8749-9737$$aRicceri, Fulvio$$b18
000153590 7001_ $$avan Gils, Carla H$$b19
000153590 7001_ $$aMonninkhof, Evelyn M$$b20
000153590 7001_ $$aBonet, Catalina$$b21
000153590 7001_ $$aQuirós, J Ramón$$b22
000153590 7001_ $$aSanchez, Maria-Jose$$b23
000153590 7001_ $$aRodríguez-Palacios, Daniel-Ángel$$b24
000153590 7001_ $$aBarricarte, Aurelio$$b25
000153590 7001_ $$aAmiano, Pilar$$b26
000153590 7001_ $$aAllen, Naomi E$$b27
000153590 7001_ $$aTravis, Ruth C$$b28
000153590 7001_ $$aGunter, Marc J$$b29
000153590 7001_ $$aViallon, Vivian$$b30
000153590 7001_ $$00000-0003-2237-0128$$aWeiderpass, Elisabete$$b31
000153590 7001_ $$aRiboli, Elio$$b32
000153590 7001_ $$0P:(DE-He78)4b2dc91c9d1ac33a1c0e0777d0c1697a$$aKaaks, Rudolf$$b33$$eLast author$$udkfz
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