Journal Article

DKFZ-2020-00334

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort.

Turzanski-Fortner, R. (First author)DKFZ* ; Hüsing, A.DKFZ* ; Dossus, L. ; Tjønneland, A. ; Overvad, K. ; Dahm, C. C. ; Arveux, P. ; Fournier, A. ; Kvaskoff, M. ; Schulze, M. B. ; Bergmann, M. ; Trichopoulou, A. ; Karakatsani, A. ; La Vecchia, C. ; Masala, G. ; Pala, V. ; Mattiello, A. ; Tumino, R. ; Ricceri, F. ; van Gils, C. H. ; Monninkhof, E. M. ; Bonet, C. ; Quirós, J. R. ; Sanchez, M.-J. ; Rodríguez-Palacios, D.-Á. ; Barricarte, A. ; Amiano, P. ; Allen, N. E. ; Travis, R. C. ; Gunter, M. J. ; Viallon, V. ; Weiderpass, E. ; Riboli, E. ; Kaaks, R. (Last author)DKFZ*

2020
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.32901

Abstract: Endometrial cancer (EC) incidence rates vary ~10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low-risk countries can be explained by differences in these patterns. Predicted EC incidence rates were estimated over 10 years of follow-up for the cohort before and after modifying risk factor profiles. Risk factors considered were: body mass index (BMI, kg/m2 ), use of postmenopausal hormone therapy (HT) and oral contraceptives (OC) (potentially modifiable); and, parity, ages at first birth, menarche and menopause (environmentally conditioned, but not readily modifiable). Modeled alterations in BMI (to all ≤23 kg/m2 ) and HT use (to all non-HT users) profiles resulted in a 30% reduction in predicted EC incidence rates; individually, longer duration of OC use (to all ≥10 years) resulted in a 42.5% reduction. Modeled changes in not readily modifiable exposures (i.e., those not contributing to prevention potential) resulted in ≤24.6% reduction in predicted EC incidence. Women in the lowest decile of a risk score based on the evaluated exposures had risk similar to a low risk countries; however, this was driven by relatively long use of OCs (median = 23 years). Our findings support avoidance of overweight BMI and of HT use as prevention strategies for EC in a European population; OC use must be considered in the context of benefits and risks. This article is protected by copyright. All rights reserved.

Note: 2020 Sep 1;147(5):1325-1333#EA:C020#LA:C020#

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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