TY  - JOUR
AU  - Turzanski-Fortner, Renée
AU  - Hüsing, Anika
AU  - Dossus, Laure
AU  - Tjønneland, Anne
AU  - Overvad, Kim
AU  - Dahm, Christina C
AU  - Arveux, Patrick
AU  - Fournier, Agnès
AU  - Kvaskoff, Marina
AU  - Schulze, Matthias B
AU  - Bergmann, Manuela
AU  - Trichopoulou, Antonia
AU  - Karakatsani, Anna
AU  - La Vecchia, Carlo
AU  - Masala, Giovanna
AU  - Pala, Valeria
AU  - Mattiello, Amalia
AU  - Tumino, Rosario
AU  - Ricceri, Fulvio
AU  - van Gils, Carla H
AU  - Monninkhof, Evelyn M
AU  - Bonet, Catalina
AU  - Quirós, J Ramón
AU  - Sanchez, Maria-Jose
AU  - Rodríguez-Palacios, Daniel-Ángel
AU  - Barricarte, Aurelio
AU  - Amiano, Pilar
AU  - Allen, Naomi E
AU  - Travis, Ruth C
AU  - Gunter, Marc J
AU  - Viallon, Vivian
AU  - Weiderpass, Elisabete
AU  - Riboli, Elio
AU  - Kaaks, Rudolf
TI  - Theoretical potential for endometrial cancer prevention through primary risk factor modification: Estimates from the EPIC cohort.
JO  - International journal of cancer
VL  - 147
IS  - 5
SN  - 1097-0215
CY  - Bognor Regis
PB  - Wiley-Liss
M1  - DKFZ-2020-00334
SP  - 1325-1333
PY  - 2020
N1  - 2020 Sep 1;147(5):1325-1333#EA:C020#LA:C020#
AB  - Endometrial cancer (EC) incidence rates vary  10-fold worldwide, in part due to variation in EC risk factor profiles. Using an EC risk model previously developed in the European EPIC cohort, we evaluated the prevention potential of modified EC risk factor patterns and whether differences in EC incidence between a European population and low-risk countries can be explained by differences in these patterns. Predicted EC incidence rates were estimated over 10 years of follow-up for the cohort before and after modifying risk factor profiles. Risk factors considered were: body mass index (BMI, kg/m2 ), use of postmenopausal hormone therapy (HT) and oral contraceptives (OC) (potentially modifiable); and, parity, ages at first birth, menarche and menopause (environmentally conditioned, but not readily modifiable). Modeled alterations in BMI (to all ≤23 kg/m2 ) and HT use (to all non-HT users) profiles resulted in a 30
LB  - PUB:(DE-HGF)16
C6  - pmid:32011733
DO  - DOI:10.1002/ijc.32901
UR  - https://inrepo02.dkfz.de/record/153590
ER  -