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@ARTICLE{TurzanskiFortner:153590,
      author       = {R. Turzanski-Fortner$^*$ and A. Hüsing$^*$ and L. Dossus
                      and A. Tjønneland and K. Overvad and C. C. Dahm and P.
                      Arveux and A. Fournier and M. Kvaskoff and M. B. Schulze and
                      M. Bergmann and A. Trichopoulou and A. Karakatsani and C. La
                      Vecchia and G. Masala and V. Pala and A. Mattiello and R.
                      Tumino and F. Ricceri and C. H. van Gils and E. M.
                      Monninkhof and C. Bonet and J. R. Quirós and M.-J. Sanchez
                      and D.-Á. Rodríguez-Palacios and A. Barricarte and P.
                      Amiano and N. E. Allen and R. C. Travis and M. J. Gunter and
                      V. Viallon and E. Weiderpass and E. Riboli and R. Kaaks$^*$},
      title        = {{T}heoretical potential for endometrial cancer prevention
                      through primary risk factor modification: {E}stimates from
                      the {EPIC} cohort.},
      journal      = {International journal of cancer},
      volume       = {147},
      number       = {5},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-00334},
      pages        = {1325-1333},
      year         = {2020},
      note         = {2020 Sep 1;147(5):1325-1333#EA:C020#LA:C020#},
      abstract     = {Endometrial cancer (EC) incidence rates vary ~10-fold
                      worldwide, in part due to variation in EC risk factor
                      profiles. Using an EC risk model previously developed in the
                      European EPIC cohort, we evaluated the prevention potential
                      of modified EC risk factor patterns and whether differences
                      in EC incidence between a European population and low-risk
                      countries can be explained by differences in these patterns.
                      Predicted EC incidence rates were estimated over 10 years
                      of follow-up for the cohort before and after modifying risk
                      factor profiles. Risk factors considered were: body mass
                      index (BMI, kg/m2 ), use of postmenopausal hormone therapy
                      (HT) and oral contraceptives (OC) (potentially modifiable);
                      and, parity, ages at first birth, menarche and menopause
                      (environmentally conditioned, but not readily modifiable).
                      Modeled alterations in BMI (to all ≤23 kg/m2 ) and HT
                      use (to all non-HT users) profiles resulted in a $30\%$
                      reduction in predicted EC incidence rates; individually,
                      longer duration of OC use (to all ≥10 years) resulted in
                      a $42.5\%$ reduction. Modeled changes in not readily
                      modifiable exposures (i.e., those not contributing to
                      prevention potential) resulted in $≤24.6\%$ reduction in
                      predicted EC incidence. Women in the lowest decile of a risk
                      score based on the evaluated exposures had risk similar to a
                      low risk countries; however, this was driven by relatively
                      long use of OCs (median = 23 years). Our findings
                      support avoidance of overweight BMI and of HT use as
                      prevention strategies for EC in a European population; OC
                      use must be considered in the context of benefits and risks.
                      This article is protected by copyright. All rights
                      reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32011733},
      doi          = {10.1002/ijc.32901},
      url          = {https://inrepo02.dkfz.de/record/153590},
}