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000153716 1001_ $$aBoekstegers, Felix$$b0
000153716 245__ $$aABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.
000153716 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2020
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000153716 520__ $$aThe first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
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000153716 7001_ $$aMarcelain, Katherine$$b1
000153716 7001_ $$aBarahona Ponce, Carol$$b2
000153716 7001_ $$aBaez Benavides, Pablo F$$b3
000153716 7001_ $$aMüller, Bettina$$b4
000153716 7001_ $$ade Toro, Gonzalo$$b5
000153716 7001_ $$aRetamales, Javier$$b6
000153716 7001_ $$aBarajas, Olga$$b7
000153716 7001_ $$aAhumada, Monica$$b8
000153716 7001_ $$aMorales, Erik$$b9
000153716 7001_ $$aRojas, Armando$$b10
000153716 7001_ $$aSanhueza, Verónica$$b11
000153716 7001_ $$aLoader, Denisse$$b12
000153716 7001_ $$aRivera, María Teresa$$b13
000153716 7001_ $$aGutiérrez, Lorena$$b14
000153716 7001_ $$aBernal, Giuliano$$b15
000153716 7001_ $$aOrtega, Alejandro$$b16
000153716 7001_ $$aMontalvo, Domingo$$b17
000153716 7001_ $$aPortiño, Sergio$$b18
000153716 7001_ $$aBertrán, Maria Enriqueta$$b19
000153716 7001_ $$aGabler, Fernando$$b20
000153716 7001_ $$aSpencer, Loreto$$b21
000153716 7001_ $$aOlloquequi, Jordi$$b22
000153716 7001_ $$aGonzález Silos, Rosa$$b23
000153716 7001_ $$aFischer, Christine$$b24
000153716 7001_ $$aScherer, Dominique$$b25
000153716 7001_ $$aJenab, Mazda$$b26
000153716 7001_ $$aAleksandrova, Krasimira$$b27
000153716 7001_ $$0P:(DE-He78)fb68a9386399d72d84f7f34cfc6048b4$$aKatzke, Verena$$b28$$udkfz
000153716 7001_ $$aWeiderpass, Elisabete$$b29
000153716 7001_ $$aMoradi, Tahereh$$b30
000153716 7001_ $$aFischer, Krista$$b31
000153716 7001_ $$aBossers, Willem$$b32
000153716 7001_ $$0P:(DE-He78)90d5535ff896e70eed81f4a4f6f22ae2$$aBrenner, Hermann$$b33$$udkfz
000153716 7001_ $$aHveem, Kristian$$b34
000153716 7001_ $$aEklund, Niina$$b35
000153716 7001_ $$aVölker, Uwe$$b36
000153716 7001_ $$aWaldenberger, Melanie$$b37
000153716 7001_ $$aFuentes Guajardo, Macarena$$b38
000153716 7001_ $$aGonzalez-Jose, Rolando$$b39
000153716 7001_ $$aBedoya, Gabriel$$b40
000153716 7001_ $$aBortolini, Maria C$$b41
000153716 7001_ $$aCanizales, Samuel$$b42
000153716 7001_ $$aGallo, Carla$$b43
000153716 7001_ $$aRuiz Linares, Andres$$b44
000153716 7001_ $$aRothhammer, Francisco$$b45
000153716 7001_ $$aLorenzo Bermejo, Justo$$b46
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