Journal Article

DKFZ-2020-00413

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.

Boekstegers, F. ; Marcelain, K. ; Barahona Ponce, C. ; Baez Benavides, P. F. ; Müller, B. ; de Toro, G. ; Retamales, J. ; Barajas, O. ; Ahumada, M. ; Morales, E. ; Rojas, A. ; Sanhueza, V. ; Loader, D. ; Rivera, M. T. ; Gutiérrez, L. ; Bernal, G. ; Ortega, A. ; Montalvo, D. ; Portiño, S. ; Bertrán, M. E. ; Gabler, F. ; Spencer, L. ; Olloquequi, J. ; González Silos, R. ; Fischer, C. ; Scherer, D. ; Jenab, M. ; Aleksandrova, K. ; Katzke, V.DKFZ* ; Weiderpass, E. ; Moradi, T. ; Fischer, K. ; Bossers, W. ; Brenner, H.DKFZ* ; Hveem, K. ; Eklund, N. ; Völker, U. ; Waldenberger, M. ; Fuentes Guajardo, M. ; Gonzalez-Jose, R. ; Bedoya, G. ; Bortolini, M. C. ; Canizales, S. ; Gallo, C. ; Ruiz Linares, A. ; Rothhammer, F. ; Lorenzo Bermejo, J.

2020
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.canep.2019.101643

Abstract: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C070 Klinische Epidemiologie und Alternf. (C070)
3. Präventive Onkologie (C120)
4. DKTK HD zentral (HD01)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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