TY  - JOUR
AU  - Boekstegers, Felix
AU  - Marcelain, Katherine
AU  - Barahona Ponce, Carol
AU  - Baez Benavides, Pablo F
AU  - Müller, Bettina
AU  - de Toro, Gonzalo
AU  - Retamales, Javier
AU  - Barajas, Olga
AU  - Ahumada, Monica
AU  - Morales, Erik
AU  - Rojas, Armando
AU  - Sanhueza, Verónica
AU  - Loader, Denisse
AU  - Rivera, María Teresa
AU  - Gutiérrez, Lorena
AU  - Bernal, Giuliano
AU  - Ortega, Alejandro
AU  - Montalvo, Domingo
AU  - Portiño, Sergio
AU  - Bertrán, Maria Enriqueta
AU  - Gabler, Fernando
AU  - Spencer, Loreto
AU  - Olloquequi, Jordi
AU  - González Silos, Rosa
AU  - Fischer, Christine
AU  - Scherer, Dominique
AU  - Jenab, Mazda
AU  - Aleksandrova, Krasimira
AU  - Katzke, Verena
AU  - Weiderpass, Elisabete
AU  - Moradi, Tahereh
AU  - Fischer, Krista
AU  - Bossers, Willem
AU  - Brenner, Hermann
AU  - Hveem, Kristian
AU  - Eklund, Niina
AU  - Völker, Uwe
AU  - Waldenberger, Melanie
AU  - Fuentes Guajardo, Macarena
AU  - Gonzalez-Jose, Rolando
AU  - Bedoya, Gabriel
AU  - Bortolini, Maria C
AU  - Canizales, Samuel
AU  - Gallo, Carla
AU  - Ruiz Linares, Andres
AU  - Rothhammer, Francisco
AU  - Lorenzo Bermejo, Justo
TI  - ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans.
JO  - Cancer epidemiology
VL  - 65
SN  - 1877-7821
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - DKFZ-2020-00413
SP  - 101643 
PY  - 2020
AB  - The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence.This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication.Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low.Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
LB  - PUB:(DE-HGF)16
C6  - pmid:32058310
DO  - DOI:10.1016/j.canep.2019.101643
UR  - https://inrepo02.dkfz.de/record/153716
ER  -