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@ARTICLE{Boekstegers:153716,
      author       = {F. Boekstegers and K. Marcelain and C. Barahona Ponce and
                      P. F. Baez Benavides and B. Müller and G. de Toro and J.
                      Retamales and O. Barajas and M. Ahumada and E. Morales and
                      A. Rojas and V. Sanhueza and D. Loader and M. T. Rivera and
                      L. Gutiérrez and G. Bernal and A. Ortega and D. Montalvo
                      and S. Portiño and M. E. Bertrán and F. Gabler and L.
                      Spencer and J. Olloquequi and R. González Silos and C.
                      Fischer and D. Scherer and M. Jenab and K. Aleksandrova and
                      V. Katzke$^*$ and E. Weiderpass and T. Moradi and K. Fischer
                      and W. Bossers and H. Brenner$^*$ and K. Hveem and N. Eklund
                      and U. Völker and M. Waldenberger and M. Fuentes Guajardo
                      and R. Gonzalez-Jose and G. Bedoya and M. C. Bortolini and
                      S. Canizales and C. Gallo and A. Ruiz Linares and F.
                      Rothhammer and J. Lorenzo Bermejo},
      title        = {{ABCB}1/4 gallbladder cancer risk variants identified in
                      {I}ndia also show strong effects in {C}hileans.},
      journal      = {Cancer epidemiology},
      volume       = {65},
      issn         = {1877-7821},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-00413},
      pages        = {101643},
      year         = {2020},
      abstract     = {The first large-scale genome-wide association study of
                      gallbladder cancer (GBC) recently identified and validated
                      three susceptibility variants in the ABCB1 and ABCB4 genes
                      for individuals of Indian descent. We investigated whether
                      these variants were also associated with GBC risk in
                      Chileans, who show the highest incidence of GBC worldwide,
                      and in Europeans with a low GBC incidence.This
                      population-based study analysed genotype data from
                      retrospective Chilean case-control (255 cases, 2042
                      controls) and prospective European cohort (108 cases, 181
                      controls) samples consistently with the original
                      publication.Our results confirmed the reported associations
                      for Chileans with similar risk effects. Particularly strong
                      associations (per-allele odds ratios close to 2) were
                      observed for Chileans with high Native American (=Mapuche)
                      ancestry. No associations were noticed for Europeans, but
                      the statistical power was low.Taking full advantage of
                      genetic and ethnic differences in GBC risk may improve the
                      efficiency of current prevention programs.},
      cin          = {C020 / C070 / C120 / HD01},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331 /
                      I:(DE-He78)C120-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32058310},
      doi          = {10.1016/j.canep.2019.101643},
      url          = {https://inrepo02.dkfz.de/record/153716},
}