%0 Journal Article
%A Packer, Roger J
%A Iavarone, Antonio
%A Jones, David T W
%A Blakeley, Jaishri O
%A Bouffet, Eric
%A Fisher, Michael J
%A Hwang, Eugene
%A Hawkins, Cynthia
%A Kilburn, Lindsay
%A MacDonald, Tobey
%A Pfister, Stefan M
%A Rood, Brian
%A Rodriguez, Fausto J
%A Tabori, Uri
%A Ramaswamy, Vijay
%A Zhu, Yuan
%A Fangusaro, Jason
%A Johnston, Stephen A
%A Gutmann, David H
%T Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference.
%J Neuro-Oncology
%V 22
%N 6
%@ 1523-5866
%C Oxford
%I Oxford Univ. Press
%M DKFZ-2020-00416
%P 773-784
%D 2020
%Z 2020 Jun 9;22(6):773-784
%X Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type I (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low grade 'transformed' and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecular targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32055852
%R 10.1093/neuonc/noaa036
%U https://inrepo02.dkfz.de/record/153719