Journal Article

DKFZ-2020-00416

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference.

Packer, R. J. ; Iavarone, A. ; Jones, D. T. W.DKFZ* ; Blakeley, J. O. ; Bouffet, E. ; Fisher, M. J. ; Hwang, E. ; Hawkins, C. ; Kilburn, L. ; MacDonald, T. ; Pfister, S. M.DKFZ* ; Rood, B. ; Rodriguez, F. J. ; Tabori, U. ; Ramaswamy, V. ; Zhu, Y. ; Fangusaro, J. ; Johnston, S. A. ; Gutmann, D. H.

2020
Oxford Univ. Press Oxford

This record in other databases:  

Please use a persistent id in citations: doi:10.1093/neuonc/noaa036

Abstract: Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type I (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low grade 'transformed' and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecular targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.

Note: 2020 Jun 9;22(6):773-784

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Contributing Institute(s):

1. Pediatric Glioma (B360)
2. B062 Pädiatrische Neuroonkologie (B062)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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