TY  - JOUR
AU  - Packer, Roger J
AU  - Iavarone, Antonio
AU  - Jones, David T W
AU  - Blakeley, Jaishri O
AU  - Bouffet, Eric
AU  - Fisher, Michael J
AU  - Hwang, Eugene
AU  - Hawkins, Cynthia
AU  - Kilburn, Lindsay
AU  - MacDonald, Tobey
AU  - Pfister, Stefan M
AU  - Rood, Brian
AU  - Rodriguez, Fausto J
AU  - Tabori, Uri
AU  - Ramaswamy, Vijay
AU  - Zhu, Yuan
AU  - Fangusaro, Jason
AU  - Johnston, Stephen A
AU  - Gutmann, David H
TI  - Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference.
JO  - Neuro-Oncology
VL  - 22
IS  - 6
SN  - 1523-5866
CY  - Oxford
PB  - Oxford Univ. Press
M1  - DKFZ-2020-00416
SP  - 773-784
PY  - 2020
N1  - 2020 Jun 9;22(6):773-784
AB  - Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type I (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low grade 'transformed' and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecular targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.
LB  - PUB:(DE-HGF)16
C6  - pmid:32055852
DO  - DOI:10.1093/neuonc/noaa036
UR  - https://inrepo02.dkfz.de/record/153719
ER  -