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037 _ _ |a DKFZ-2020-00416
041 _ _ |a eng
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100 1 _ |a Packer, Roger J
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245 _ _ |a Implications of New Understandings of Gliomas in Children and Adults with NF1: Report of a Consensus Conference.
260 _ _ |a Oxford
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|b Oxford Univ. Press
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500 _ _ |a 2020 Jun 9;22(6):773-784
520 _ _ |a Gliomas are the most common primary central nervous system tumors occurring in children and adults with neurofibromatosis type I (NF1). Over the past decade, discoveries of the molecular basis of low-grade gliomas (LGGs) have led to new approaches for diagnosis and treatments. However, these new understandings have not been fully applied to the management of NF1-associated gliomas. A consensus panel consisting of experts in NF1 and gliomas was convened to review the current molecular knowledge of NF1-associated low grade 'transformed' and high-grade gliomas; insights gained from mouse models of NF1-LGGs; challenges in diagnosing and treating older patients with NF1-associated gliomas; and advances in molecular targeted treatment and potential immunologic treatment of these tumors. Next steps are recommended to advance the management and outcomes for NF1-associated gliomas.
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700 1 _ |a Iavarone, Antonio
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700 1 _ |a Jones, David T W
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700 1 _ |a Blakeley, Jaishri O
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700 1 _ |a Bouffet, Eric
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700 1 _ |a Fisher, Michael J
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700 1 _ |a Hwang, Eugene
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700 1 _ |a Hawkins, Cynthia
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700 1 _ |a Kilburn, Lindsay
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700 1 _ |a MacDonald, Tobey
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700 1 _ |a Pfister, Stefan M
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700 1 _ |a Rood, Brian
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700 1 _ |a Rodriguez, Fausto J
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700 1 _ |a Tabori, Uri
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700 1 _ |a Ramaswamy, Vijay
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700 1 _ |a Zhu, Yuan
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700 1 _ |a Fangusaro, Jason
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700 1 _ |a Johnston, Stephen A
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700 1 _ |a Gutmann, David H
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773 _ _ |a 10.1093/neuonc/noaa036
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