Journal Article

DKFZ-2020-00525

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png First-line therapy with Bendamustine/Prednisone/Bortezomib (BPV) - A GMMG trial for non-transplant eligible symptomatic multiple myeloma patients.

Knauf, W. ; Dingeldein, G. ; Schlag, R. ; Welslau, M. ; Moehler, T. ; Terzer, T.DKFZ* ; Walter, S. ; Goldschmidt, H. ; Raab, M.-S. ; group, B. t.

2020
Wiley-Blackwell Oxford

This record in other databases:  

Please use a persistent id in citations: doi:10.1111/ejh.13409

Abstract: The German-speaking Myeloma Multicenter Group (GMMG) conducted this trial to investigate efficacy and safety of the 3-drug-combination bendamustine/prednisone/bortezomib (BPV) as first-line therapy for elderly patients with multiple myeloma (MM).Elderly MM patients requiring first-line therapy and not eligible for intensive treatment were enrolled in this phase IIb multicenter study. Patients were treated with BPV regimen for a maximum of 9 cycles.46 patients were included into the trial with a median age of 76 years. 19 patients had renal impairment at baseline. The ORR was 76.5%, the median progression free survival 25 months and overall survival at 24 month 83.3%. The clinical benefit rate (CBR) including MR was 91.2%. In patients with renal impairment at baseline a renal response was observed in 11 pts. with complete recovery of the renal function in 6 patients. The most frequent CTC grade 3/4 AEs experienced by patients were hematological (17.5%) and infectious (9.8%) complications. No new safety signals were observed for the study drugs under investigation.BPV may serve as a first-line regimen for transplant ineligible elderly MM patients in particular for patients with renal impairment requiring a fast and durable renal response.

Note: 2020 Aug;105(2):116-125

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Contributing Institute(s):

1. C060 Biostatistik (C060)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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