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000153956 0247_ $$2doi$$a10.3389/fonc.2019.01539
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000153956 1001_ $$aMoore, Amy$$b0
000153956 245__ $$aGenetically Determined Height and Risk of Non-hodgkin Lymphoma.
000153956 260__ $$aLausanne$$bFrontiers Media$$c2020
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000153956 520__ $$aAlthough the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
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000153956 7001_ $$aKane, Eleanor$$b1
000153956 7001_ $$aWang, Zhaoming$$b2
000153956 7001_ $$aPanagiotou, Orestis A$$b3
000153956 7001_ $$aTeras, Lauren R$$b4
000153956 7001_ $$aMonnereau, Alain$$b5
000153956 7001_ $$aWong Doo, Nicole$$b6
000153956 7001_ $$aMachiela, Mitchell J$$b7
000153956 7001_ $$aSkibola, Christine F$$b8
000153956 7001_ $$aSlager, Susan L$$b9
000153956 7001_ $$aSalles, Gilles$$b10
000153956 7001_ $$aCamp, Nicola J$$b11
000153956 7001_ $$aBracci, Paige M$$b12
000153956 7001_ $$aNieters, Alexandra$$b13
000153956 7001_ $$aVermeulen, Roel C H$$b14
000153956 7001_ $$aVijai, Joseph$$b15
000153956 7001_ $$aSmedby, Karin E$$b16
000153956 7001_ $$aZhang, Yawei$$b17
000153956 7001_ $$aVajdic, Claire M$$b18
000153956 7001_ $$aCozen, Wendy$$b19
000153956 7001_ $$aSpinelli, John J$$b20
000153956 7001_ $$aHjalgrim, Henrik$$b21
000153956 7001_ $$aGiles, Graham G$$b22
000153956 7001_ $$aLink, Brian K$$b23
000153956 7001_ $$aClavel, Jacqueline$$b24
000153956 7001_ $$aArslan, Alan A$$b25
000153956 7001_ $$aPurdue, Mark P$$b26
000153956 7001_ $$aTinker, Lesley F$$b27
000153956 7001_ $$aAlbanes, Demetrius$$b28
000153956 7001_ $$aFerri, Giovanni M$$b29
000153956 7001_ $$aHabermann, Thomas M$$b30
000153956 7001_ $$aAdami, Hans-Olov$$b31
000153956 7001_ $$0P:(DE-He78)1573258b58c33f1922ca9719d0c8c4ab$$aBecker, Nikolaus$$b32$$udkfz
000153956 7001_ $$aBenavente, Yolanda$$b33
000153956 7001_ $$aBisanzi, Simonetta$$b34
000153956 7001_ $$aBoffetta, Paolo$$b35
000153956 7001_ $$aBrennan, Paul$$b36
000153956 7001_ $$aBrooks-Wilson, Angela R$$b37
000153956 7001_ $$0P:(DE-He78)5323704270b6393dcea70186ffd86bca$$aCanzian, Federico$$b38$$udkfz
000153956 7001_ $$aConde, Lucia$$b39
000153956 7001_ $$aCox, David G$$b40
000153956 7001_ $$aCurtin, Karen$$b41
000153956 7001_ $$aForetova, Lenka$$b42
000153956 7001_ $$aGapstur, Susan M$$b43
000153956 7001_ $$aGhesquières, Hervé$$b44
000153956 7001_ $$aGlenn, Martha$$b45
000153956 7001_ $$aGlimelius, Bengt$$b46
000153956 7001_ $$aJackson, Rebecca D$$b47
000153956 7001_ $$aLan, Qing$$b48
000153956 7001_ $$aLiebow, Mark$$b49
000153956 7001_ $$aMaynadie, Marc$$b50
000153956 7001_ $$aMcKay, James$$b51
000153956 7001_ $$aMelbye, Mads$$b52
000153956 7001_ $$aMiligi, Lucia$$b53
000153956 7001_ $$aMilne, Roger L$$b54
000153956 7001_ $$aMolina, Thierry J$$b55
000153956 7001_ $$aMorton, Lindsay M$$b56
000153956 7001_ $$aNorth, Kari E$$b57
000153956 7001_ $$aOffit, Kenneth$$b58
000153956 7001_ $$aPadoan, Marina$$b59
000153956 7001_ $$aPatel, Alpa V$$b60
000153956 7001_ $$aPiro, Sara$$b61
000153956 7001_ $$aRavichandran, Vignesh$$b62
000153956 7001_ $$aRiboli, Elio$$b63
000153956 7001_ $$ade Sanjose, Silvia$$b64
000153956 7001_ $$aSeverson, Richard K$$b65
000153956 7001_ $$aSouthey, Melissa C$$b66
000153956 7001_ $$aStaines, Anthony$$b67
000153956 7001_ $$aStewart, Carolyn$$b68
000153956 7001_ $$aTravis, Ruth C$$b69
000153956 7001_ $$aWeiderpass, Elisabete$$b70
000153956 7001_ $$aWeinstein, Stephanie$$b71
000153956 7001_ $$aZheng, Tongzhang$$b72
000153956 7001_ $$aChanock, Stephen J$$b73
000153956 7001_ $$aChatterjee, Nilanjan$$b74
000153956 7001_ $$aRothman, Nathaniel$$b75
000153956 7001_ $$aBirmann, Brenda M$$b76
000153956 7001_ $$aCerhan, James R$$b77
000153956 7001_ $$aBerndt, Sonja I$$b78
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