Journal Article

DKFZ-2020-00546

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genetically Determined Height and Risk of Non-hodgkin Lymphoma.

Moore, A. ; Kane, E. ; Wang, Z. ; Panagiotou, O. A. ; Teras, L. R. ; Monnereau, A. ; Wong Doo, N. ; Machiela, M. J. ; Skibola, C. F. ; Slager, S. L. ; Salles, G. ; Camp, N. J. ; Bracci, P. M. ; Nieters, A. ; Vermeulen, R. C. H. ; Vijai, J. ; Smedby, K. E. ; Zhang, Y. ; Vajdic, C. M. ; Cozen, W. ; Spinelli, J. J. ; Hjalgrim, H. ; Giles, G. G. ; Link, B. K. ; Clavel, J. ; Arslan, A. A. ; Purdue, M. P. ; Tinker, L. F. ; Albanes, D. ; Ferri, G. M. ; Habermann, T. M. ; Adami, H.-O. ; Becker, N.DKFZ* ; Benavente, Y. ; Bisanzi, S. ; Boffetta, P. ; Brennan, P. ; Brooks-Wilson, A. R. ; Canzian, F.DKFZ* ; Conde, L. ; Cox, D. G. ; Curtin, K. ; Foretova, L. ; Gapstur, S. M. ; Ghesquières, H. ; Glenn, M. ; Glimelius, B. ; Jackson, R. D. ; Lan, Q. ; Liebow, M. ; Maynadie, M. ; McKay, J. ; Melbye, M. ; Miligi, L. ; Milne, R. L. ; Molina, T. J. ; Morton, L. M. ; North, K. E. ; Offit, K. ; Padoan, M. ; Patel, A. V. ; Piro, S. ; Ravichandran, V. ; Riboli, E. ; de Sanjose, S. ; Severson, R. K. ; Southey, M. C. ; Staines, A. ; Stewart, C. ; Travis, R. C. ; Weiderpass, E. ; Weinstein, S. ; Zheng, T. ; Chanock, S. J. ; Chatterjee, N. ; Rothman, N. ; Birmann, B. M. ; Cerhan, J. R. ; Berndt, S. I.

2020
Frontiers Media Lausanne

This record in other databases:  

Please use a persistent id in citations: doi:10.3389/fonc.2019.01539

Abstract: Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C055 Genomische Epidemiologie (C055)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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