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000154088 1001_ $$aCalandrini, Camilla$$b0
000154088 245__ $$aAn organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
000154088 260__ $$a[London]$$bNature Publishing Group UK$$c2020
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000154088 520__ $$aKidney tumours are among the most common solid tumours in children, comprising distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first paediatric cancer organoid biobank. It contains tumour and matching normal kidney organoids from over 50 children with different subtypes of kidney cancer, including Wilms tumours, malignant rhabdoid tumours, renal cell carcinomas, and congenital mesoblastic nephromas. Paediatric kidney tumour organoids retain key properties of native tumours, useful for revealing patient-specific drug sensitivities. Using single cell RNA-sequencing and high resolution 3D imaging, we further demonstrate that organoid cultures derived from Wilms tumours consist of multiple different cell types, including epithelial, stromal and blastemal-like cells. Our organoid biobank captures the heterogeneity of paediatric kidney tumours, providing a representative collection of well-characterised models for basic cancer research, drug-screening and personalised medicine.
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000154088 7001_ $$aSchutgens, Frans$$b1
000154088 7001_ $$00000-0003-4107-7250$$aOka, Rurika$$b2
000154088 7001_ $$aMargaritis, Thanasis$$b3
000154088 7001_ $$aCandelli, Tito$$b4
000154088 7001_ $$aMathijsen, Luka$$b5
000154088 7001_ $$aAmmerlaan, Carola$$b6
000154088 7001_ $$avan Ineveld, Ravian L$$b7
000154088 7001_ $$aDerakhshan, Sepide$$b8
000154088 7001_ $$ade Haan, Sanne$$b9
000154088 7001_ $$aDolman, Emmy$$b10
000154088 7001_ $$aLijnzaad, Philip$$b11
000154088 7001_ $$aCusters, Lars$$b12
000154088 7001_ $$aBegthel, Harry$$b13
000154088 7001_ $$aKerstens, Hindrik H D$$b14
000154088 7001_ $$00000-0001-7856-1981$$aVisser, Lindy L$$b15
000154088 7001_ $$aRookmaaker, Maarten$$b16
000154088 7001_ $$00000-0002-3276-6428$$aVerhaar, Marianne$$b17
000154088 7001_ $$aTytgat, Godelieve A M$$b18
000154088 7001_ $$00000-0003-2237-7354$$aKemmeren, Patrick$$b19
000154088 7001_ $$ade Krijger, Ronald R$$b20
000154088 7001_ $$00000-0002-0816-5649$$aAl-Saadi, Reem$$b21
000154088 7001_ $$00000-0002-2384-9475$$aPritchard-Jones, Kathy$$b22
000154088 7001_ $$0P:(DE-He78)4c28e2aade5f44d8eca9dd8e97638ec8$$aKool, Marcel$$b23$$udkfz
000154088 7001_ $$aRios, Anne C$$b24
000154088 7001_ $$avan den Heuvel-Eibrink, Marry M$$b25
000154088 7001_ $$aMolenaar, Jan J$$b26
000154088 7001_ $$00000-0003-1285-2836$$avan Boxtel, Ruben$$b27
000154088 7001_ $$00000-0002-8090-5146$$aHolstege, Frank C P$$b28
000154088 7001_ $$00000-0002-3077-5582$$aClevers, Hans$$b29
000154088 7001_ $$aDrost, Jarno$$b30
000154088 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-15155-6$$gVol. 11, no. 1, p. 1310$$n1$$p1310$$tNature Communications$$v11$$x2041-1723$$y2020
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