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@ARTICLE{Calandrini:154088,
      author       = {C. Calandrini and F. Schutgens and R. Oka and T. Margaritis
                      and T. Candelli and L. Mathijsen and C. Ammerlaan and R. L.
                      van Ineveld and S. Derakhshan and S. de Haan and E. Dolman
                      and P. Lijnzaad and L. Custers and H. Begthel and H. H. D.
                      Kerstens and L. L. Visser and M. Rookmaaker and M. Verhaar
                      and G. A. M. Tytgat and P. Kemmeren and R. R. de Krijger and
                      R. Al-Saadi and K. Pritchard-Jones and M. Kool$^*$ and A. C.
                      Rios and M. M. van den Heuvel-Eibrink and J. J. Molenaar and
                      R. van Boxtel and F. C. P. Holstege and H. Clevers and J.
                      Drost},
      title        = {{A}n organoid biobank for childhood kidney cancers that
                      captures disease and tissue heterogeneity.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {DKFZ-2020-00554},
      pages        = {1310},
      year         = {2020},
      abstract     = {Kidney tumours are among the most common solid tumours in
                      children, comprising distinct subtypes differing in many
                      aspects, including cell-of-origin, genetics, and pathology.
                      Pre-clinical cell models capturing the disease heterogeneity
                      are currently lacking. Here, we describe the first
                      paediatric cancer organoid biobank. It contains tumour and
                      matching normal kidney organoids from over 50 children with
                      different subtypes of kidney cancer, including Wilms
                      tumours, malignant rhabdoid tumours, renal cell carcinomas,
                      and congenital mesoblastic nephromas. Paediatric kidney
                      tumour organoids retain key properties of native tumours,
                      useful for revealing patient-specific drug sensitivities.
                      Using single cell RNA-sequencing and high resolution 3D
                      imaging, we further demonstrate that organoid cultures
                      derived from Wilms tumours consist of multiple different
                      cell types, including epithelial, stromal and blastemal-like
                      cells. Our organoid biobank captures the heterogeneity of
                      paediatric kidney tumours, providing a representative
                      collection of well-characterised models for basic cancer
                      research, drug-screening and personalised medicine.},
      cin          = {B062 / HD01},
      ddc          = {500},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)HD01-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32161258},
      doi          = {10.1038/s41467-020-15155-6},
      url          = {https://inrepo02.dkfz.de/record/154088},
}