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@ARTICLE{Blocka:154270,
      author       = {J. Blocka and T. Hielscher$^*$ and H. Goldschmidt and N. C.
                      f. T. D. Department of Hematology and Oncology and J.
                      Hillengass},
      title        = {{R}esponse improvement rather than response status after
                      1st {ASCT} is a significant prognostic factor for survival
                      benefit from tandem compared to single {ASCT} in multiple
                      myeloma patients.},
      journal      = {Biology of blood and marrow transplantation},
      volume       = {26},
      number       = {7},
      issn         = {1083-8791},
      address      = {[S.l.]},
      publisher    = {Elsevier Health Sciences},
      reportid     = {DKFZ-2020-00697},
      pages        = {1280-1287},
      year         = {2020},
      note         = {2020 Jul;26(7):1280-1287},
      abstract     = {High-dose chemotherapy and autologous stem cell
                      transplantation (ASCT) have been an effective treatment for
                      newly diagnosed multiple myeloma patients for over three
                      decades. However, it remains unclear which patients benefit
                      from tandem compared to single ASCT. Here, we
                      retrospectively analyzed 978 trial and non-trial patients
                      who underwent single or tandem ASCT in Heidelberg or other
                      German Speaking Myeloma Multicenter Group centers. Our
                      results show that response improvement after 1st ASCT is a
                      significant prognostic factor for progression-free survival
                      benefit from tandem versus single ASCT (multivariable
                      analysis p = 0.002, HR = 0.64, 95 $\%$ CI [0.48,
                      0.85], interaction p = 0.02). Depth of response after
                      1st ASCT and cytogenetic profile did not have a significant
                      prognostic effect on survival benefit from tandem ASCT. In
                      conclusion, our results suggest that not the response depth
                      but rather response improvement after 1st ASCT is of
                      prognostic significance regarding the benefit of tandem
                      versus single ASCT.},
      cin          = {C060},
      ddc          = {610},
      cid          = {I:(DE-He78)C060-20160331},
      pnm          = {313 - Cancer risk factors and prevention (POF3-313)},
      pid          = {G:(DE-HGF)POF3-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32194287},
      doi          = {10.1016/j.bbmt.2020.03.006},
      url          = {https://inrepo02.dkfz.de/record/154270},
}