Journal Article

DKFZ-2020-00697

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Response improvement rather than response status after 1st ASCT is a significant prognostic factor for survival benefit from tandem compared to single ASCT in multiple myeloma patients.

Blocka, J. ; Hielscher, T.DKFZ* ; Goldschmidt, H. ; Department of Hematology and Oncology, N. C. f. T. D. ; Hillengass, J.

2020
Elsevier Health Sciences [S.l.]

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Please use a persistent id in citations: doi:10.1016/j.bbmt.2020.03.006

Abstract: High-dose chemotherapy and autologous stem cell transplantation (ASCT) have been an effective treatment for newly diagnosed multiple myeloma patients for over three decades. However, it remains unclear which patients benefit from tandem compared to single ASCT. Here, we retrospectively analyzed 978 trial and non-trial patients who underwent single or tandem ASCT in Heidelberg or other German Speaking Myeloma Multicenter Group centers. Our results show that response improvement after 1st ASCT is a significant prognostic factor for progression-free survival benefit from tandem versus single ASCT (multivariable analysis p = 0.002, HR = 0.64, 95 % CI [0.48, 0.85], interaction p = 0.02). Depth of response after 1st ASCT and cytogenetic profile did not have a significant prognostic effect on survival benefit from tandem ASCT. In conclusion, our results suggest that not the response depth but rather response improvement after 1st ASCT is of prognostic significance regarding the benefit of tandem versus single ASCT.

Note: 2020 Jul;26(7):1280-1287

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Contributing Institute(s):

1. C060 Biostatistik (C060)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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