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@ARTICLE{Clarke:154386,
      author       = {M. Clarke and A. Mackay and B. Ismer and J. C. Pickles and
                      R. G. Tatevossian and S. Newman and T. A. Bale and I. Stoler
                      and E. Izquierdo and S. Temelso and D. M. Carvalho and V.
                      Molinari and A. Burford and L. Howell and A. Virasami and A.
                      R. Fairchild and A. Avery and J. Chalker and M. Kristiansen
                      and K. Haupfear and J. D. Dalton and W. Orisme and J. Wen
                      and M. Hubank and K. M. Kurian and C. Rowe and M. Maybury
                      and S. Crosier and J. Knipstein and U. Schuller and U.
                      Kordes and D. E. Kram and M. Snuderl and L. Bridges and A.
                      J. Martin and L. J. Doey and S. Al-Sarraj and C. Chandler
                      and B. Zebian and C. Cairns and R. Natrajan and J. K. Boult
                      and S. P. Robinson and M. Sill$^*$ and I. J. Dunkel and S.
                      W. Gilheeney and M. K. Rosenblum and D. Hughes and P. Z.
                      Proszek and T. J. MacDonald and M. Preusser and C. Haberler
                      and I. Slavc and R. Packer and H.-K. Ng and S. Caspi and M.
                      Popovic and B. Faganel Kotnik and M. D. Wood and L. Baird
                      and M. A. Davare and D. A. Solomon and T. K. Olsen and P.
                      Brandal and M. Farrell and J. B. Cryan and M. Capra and M.
                      Karremann and J. Schittenhelm and M. U. Schuhmann and M.
                      Ebinger and W. N. M. Dinjens and K. Kerl and S. Hettmer and
                      T. Pietsch and F. Andreiuolo and P. H. Driever and A.
                      Korshunov$^*$ and L. Hiddingh$^*$ and B. C. Worst$^*$ and D.
                      Sturm$^*$ and M. Zuckermann$^*$ and O. Witt$^*$ and T. Bloom
                      and C. Mitchell and E. Miele and G. S. Colafati and F.
                      Diomedi-Camassei and S. Bailey and A. S. Moore and T. E.
                      Hassall and S. P. Lowis and M. Tsoli and M. J. Cowley and D.
                      S. Ziegler and M. A. Karajannis and K. Aquilina and D. R.
                      Hargrave and F. Carceller and L. V. Marshall and A. von
                      Deimling$^*$ and C. M. Kramm and S. M. Pfister$^*$ and F.
                      Sahm$^*$ and S. J. Baker and A. Mastronuzzi and A. Carai and
                      M. Vinci and D. Capper$^*$ and S. Popov and D. W. Ellison
                      and T. S. Jacques and D. T. W. Jones$^*$ and C. Jones},
      title        = {{I}nfant high grade gliomas comprise multiple subgroups
                      characterized by novel targetable gene fusions and favorable
                      outcomes.},
      journal      = {Cancer discovery},
      volume       = {10},
      number       = {7},
      issn         = {2159-8290},
      address      = {Philadelphia, Pa.},
      reportid     = {DKFZ-2020-00726},
      pages        = {942-963},
      year         = {2020},
      note         = {2020 Jul;10(7):942-963},
      abstract     = {Infant high grade gliomas appear clinically distinct from
                      their counterparts in older children, indicating that
                      histopathologic grading may not accurately reflect the
                      biology of these tumors. We have collected 241 cases under 4
                      years of age, and carried out histological review,
                      methylation profiling, custom panel and genome/exome
                      sequencing. After excluding tumors representing other
                      established entities or subgroups, we identified 130 cases
                      to be part of an 'intrinsic' spectrum of disease specific to
                      the infant population. These included those with targetable
                      MAP-kinase alterations, and a large proportion of remaining
                      cases harboring gene fusions targeting ALK (n=31), NTRK1/2/3
                      (n=21), ROS1 (n=9) and MET (n=4) as their driving
                      alterations, with evidence of efficacy of targeted agents in
                      the clinic. These data strongly supports the concept that
                      infant gliomas require a change in diagnostic practice and
                      management.},
      cin          = {B062 / B300 / B360 / B310 / HD01 / BE01},
      ddc          = {610},
      cid          = {I:(DE-He78)B062-20160331 / I:(DE-He78)B300-20160331 /
                      I:(DE-He78)B360-20160331 / I:(DE-He78)B310-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)BE01-20160331},
      pnm          = {312 - Functional and structural genomics (POF3-312)},
      pid          = {G:(DE-HGF)POF3-312},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32238360},
      doi          = {10.1158/2159-8290.CD-19-1030},
      url          = {https://inrepo02.dkfz.de/record/154386},
}