Journal Article

DKFZ-2020-00726

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes.

Clarke, M. ; Mackay, A. ; Ismer, B. ; Pickles, J. C. ; Tatevossian, R. G. ; Newman, S. ; Bale, T. A. ; Stoler, I. ; Izquierdo, E. ; Temelso, S. ; Carvalho, D. M. ; Molinari, V. ; Burford, A. ; Howell, L. ; Virasami, A. ; Fairchild, A. R. ; Avery, A. ; Chalker, J. ; Kristiansen, M. ; Haupfear, K. ; Dalton, J. D. ; Orisme, W. ; Wen, J. ; Hubank, M. ; Kurian, K. M. ; Rowe, C. ; Maybury, M. ; Crosier, S. ; Knipstein, J. ; Schuller, U. ; Kordes, U. ; Kram, D. E. ; Snuderl, M. ; Bridges, L. ; Martin, A. J. ; Doey, L. J. ; Al-Sarraj, S. ; Chandler, C. ; Zebian, B. ; Cairns, C. ; Natrajan, R. ; Boult, J. K. ; Robinson, S. P. ; Sill, M.DKFZ* ; Dunkel, I. J. ; Gilheeney, S. W. ; Rosenblum, M. K. ; Hughes, D. ; Proszek, P. Z. ; MacDonald, T. J. ; Preusser, M. ; Haberler, C. ; Slavc, I. ; Packer, R. ; Ng, H.-K. ; Caspi, S. ; Popovic, M. ; Faganel Kotnik, B. ; Wood, M. D. ; Baird, L. ; Davare, M. A. ; Solomon, D. A. ; Olsen, T. K. ; Brandal, P. ; Farrell, M. ; Cryan, J. B. ; Capra, M. ; Karremann, M. ; Schittenhelm, J. ; Schuhmann, M. U. ; Ebinger, M. ; Dinjens, W. N. M. ; Kerl, K. ; Hettmer, S. ; Pietsch, T. ; Andreiuolo, F. ; Driever, P. H. ; Korshunov, A.DKFZ* ; Hiddingh, L.DKFZ* ; Worst, B. C.DKFZ* ; Sturm, D.DKFZ* ; Zuckermann, M.DKFZ* ; Witt, O.DKFZ* ; Bloom, T. ; Mitchell, C. ; Miele, E. ; Colafati, G. S. ; Diomedi-Camassei, F. ; Bailey, S. ; Moore, A. S. ; Hassall, T. E. ; Lowis, S. P. ; Tsoli, M. ; Cowley, M. J. ; Ziegler, D. S. ; Karajannis, M. A. ; Aquilina, K. ; Hargrave, D. R. ; Carceller, F. ; Marshall, L. V. ; von Deimling, A.DKFZ* ; Kramm, C. M. ; Pfister, S. M.DKFZ* ; Sahm, F.DKFZ* ; Baker, S. J. ; Mastronuzzi, A. ; Carai, A. ; Vinci, M. ; Capper, D.DKFZ* ; Popov, S. ; Ellison, D. W. ; Jacques, T. S. ; Jones, D. T. W.DKFZ* ; Jones, C.

2020
Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/2159-8290.CD-19-1030

Abstract: Infant high grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carried out histological review, methylation profiling, custom panel and genome/exome sequencing. After excluding tumors representing other established entities or subgroups, we identified 130 cases to be part of an 'intrinsic' spectrum of disease specific to the infant population. These included those with targetable MAP-kinase alterations, and a large proportion of remaining cases harboring gene fusions targeting ALK (n=31), NTRK1/2/3 (n=21), ROS1 (n=9) and MET (n=4) as their driving alterations, with evidence of efficacy of targeted agents in the clinic. These data strongly supports the concept that infant gliomas require a change in diagnostic practice and management.

Note: 2020 Jul;10(7):942-963

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Contributing Institute(s):

1. B062 Pädiatrische Neuroonkologie (B062)
2. KKE Neuropathologie (B300)
3. Pediatric Glioma (B360)
4. KKE Pädiatrische Onkologie (B310)
5. DKTK HD zentral (HD01)
6. DKTK BE zentral (BE01)

Research Program(s):

1. 312 - Functional and structural genomics (POF3-312) (POF3-312)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; IF >= 20 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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