Journal Article (Review Article)

DKFZ-2020-00747

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk: Results from the EPIC cohort.

Idahl, A. ; Cornet, C. L.DKFZ* ; Maldonado, S. G.DKFZ* ; Waterboer, T.DKFZ* ; Bender, N.DKFZ* ; Tjønneland, A. ; Hansen, L. ; Boutron-Ruault, M.-C. ; Fournier, A. ; Kvaskoff, M. ; Boeing, H. ; Trichopoulou, A. ; Valanou, E. ; Peppa, E. ; Palli, D. ; Agnoli, C. ; Mattiello, A. ; Tumino, R. ; Sacerdote, C. ; Onland-Moret, N. C. ; Gram, I. T. ; Weiderpass, E. ; Quirós, J. R. ; Duell, E. J. ; Sánchez, M.-J. ; Chirlaque, M.-D. ; Barricarte, A. ; Gil, L. ; Brändstedt, J. ; Riesbeck, K. ; Lundin, E. ; Khaw, K.-T. ; Perez-Cornago, A. ; Gunter, M. J. ; Dossus, L. ; Kaaks, R.DKFZ* ; Turzanski-Fortner, R. (Last author)DKFZ*

2020
Wiley-Liss Bognor Regis

This record in other databases:  

Please use a persistent id in citations: doi:10.1002/ijc.32999

Abstract: A substantial proportion of epithelial ovarian cancer (EOC) arises in the fallopian tube and other epithelia of the upper genital tract; these epithelia may incur damage and neoplastic transformation following sexually transmitted infections (STI) and pelvic inflammatory disease. We investigated the hypothesis that past STI infection, particularly Chlamydia trachomatis, is associated with higher EOC risk in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort including 791 cases and 1,669 matched controls. Serum antibodies against C. trachomatis, Mycoplasma genitalium, herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals [CI] comparing women with positive vs. negative serology. A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but with higher risk of the mucinous histotype (RR=2.30 [95% CI=1.22-4.32]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1) was associated with higher risk of EOC overall (1.36 [1.13-1.64]) and with the serous subtype (1.44 [1.12-1.85]). None of the other evaluated STIs were associated with EOC risk overall; however, HSV-2 was associated with higher risk of endometrioid EOC (2.35 [1.24-4.43]). The findings of this study suggest a potential role of C. trachomatis in the carcinogenesis of serous and mucinous EOC, while HSV-2 might promote the development of endometrioid disease.

Note: 147(8):2042-2052#LA:C020#

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. Infektionen und Krebs-Epidemiologie (F022)
3. Infektionen und Krebs-Epidemiologie (F020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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