Journal Article (Review Article)

DKFZ-2020-00797

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Plakophilins and their roles in diseased states.

Hofmann, I. (Last author)DKFZ*

2020
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00441-019-03153-0

Abstract: Tissue homeostasis is maintained by several cellular mechanisms and an imbalance may lead to diseased states. Here, the plakophilins 1, 2 and 3 operate as structural components and stabilize desmosomal cell-cell contacts. In their non-junctional states, they serve as regulators of signaling programs and control varied cellular processes that range from transcription, mRNA abundance, protein synthesis, growth, proliferation, migration to invasion and tumor development. Accordingly, mutations in plakophilins 1 and 2 lead to skin or heart diseases. Corresponding to their strong impact on tissue homeostasis, the expression of plakophilins is specifically deregulated in various cancer types and can be correlated with patients' survival. However, our understanding on how plakophilins contribute to tumor development, progression and metastasis in a given tumor is still in its infancy and further in-depth studies using patient-derived data together with in vitro data and animal models are required.

Note: DKFZ-ZMBH Alliance#LA:A190#

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Contributing Institute(s):

1. A190 Vaskuläre Onkologie und Metastatistierung (A190)

Research Program(s):

1. 311 - Signalling pathways, cell and tumor biology (POF3-311) (POF3-311)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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