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@ARTICLE{Kapoor:154698,
      author       = {P. M. Kapoor$^*$ and N. Mavaddat and P. P. Choudhury and A.
                      N. Wilcox and S. Lindström and S. Behrens$^*$ and K.
                      Michailidou and J. Dennis and M. K. Bolla and Q. Wang and A.
                      Jung$^*$ and Z. Abu-Ful and T. Ahearn and I. L. Andrulis and
                      H. Anton-Culver and V. Arndt$^*$ and K. J. Aronson and P. L.
                      Auer and L. E. B. Freeman and H. Becher and M. W. Beckmann
                      and A. Beeghly-Fadiel and J. Benitez and L. Bernstein and S.
                      E. Bojesen and H. Brauch$^*$ and H. Brenner$^*$ and T.
                      Brüning and Q. Cai and D. Campa and F. Canzian$^*$ and A.
                      Carracedo and B. D. Carter and J. E. Castelao and S. J.
                      Chanock and N. Chatterjee and G. Chenevix-Trench and C. L.
                      Clarke and F. J. Couch and A. Cox and S. S. Cross and K.
                      Czene and J. Y. Dai and H. S. Earp and A. B. Ekici and A. H.
                      Eliassen and M. Eriksson and D. G. Evans and P. A. Fasching
                      and J. Figueroa and L. Fritschi and M. Gabrielson and M.
                      Gago-Dominguez and C. Gao and S. M. Gapstur and M. M. Gaudet
                      and G. G. Giles and A. González-Neira and P. Guénel and L.
                      Haeberle and C. A. Haiman and N. Håkansson and P. Hall and
                      U. Hamann$^*$ and S. Hatse and J. Heyworth and B. Holleczek
                      and R. N. Hoover and J. L. Hopper and A. Howell and D. J.
                      Hunter and E. M. John and M. E. Jones and R. Kaaks$^*$ and
                      R. Keeman and C. M. Kitahara and Y.-D. Ko and S. Koutros and
                      A. W. Kurian and D. Lambrechts and L. L. Marchand and E. Lee
                      and F. Lejbkowicz and M. Linet and J. Lissowska and A.
                      Llaneza and R. J. MacInnis and M. E. Martinez and T. Maurer
                      and C. McLean and S. L. Neuhausen and W. G. Newman and A.
                      Norman and K. M. O'Brien and A. F. Olshan and J. E. Olson
                      and H. Olsson and N. Orr and C. M. Perou and G. Pita and E.
                      C. Polley and R. L. Prentice and G. Rennert and H. S.
                      Rennert and K. J. Ruddy and D. P. Sandler and C. Saunders
                      and M. J. Schoemaker and B. Schöttker$^*$ and F. Schumacher
                      and C. Scott and R. J. Scott and X.-O. Shu and A. Smeets and
                      M. C. Southey and J. J. Spinelli and J. Stone and A. J.
                      Swerdlow and R. M. Tamimi and J. A. Taylor and M. A.
                      Troester and C. M. Vachon and E. M. van Veen and X. Wang and
                      C. R. Weinberg and C. Weltens and W. Willett and S. J.
                      Winham and A. Wolk and X. R. Yang and W. Zheng and A. Ziogas
                      and A. M. Dunning and P. D. P. Pharoah and M. K. Schmidt and
                      P. Kraft and D. F. Easton and R. L. Milne and M.
                      García-Closas and J. Chang-Claude$^*$},
      collaboration = {A. Investigators and k. Investigators},
      title        = {{C}ombined associations of a polygenic risk score and
                      classical risk factors with breast cancer risk.},
      journal      = {Journal of the National Cancer Institute},
      volume       = {113},
      number       = {3},
      issn         = {1460-2105},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {DKFZ-2020-00956},
      pages        = {329–337},
      year         = {2021},
      note         = {Volume 113, Issue 3, March 2021, Pages 329–337},
      abstract     = {We evaluated the joint associations between a new
                      313-variant PRS (PRS313) and questionnaire-based breast
                      cancer risk factors for women of European ancestry, using
                      72,284 cases and 80,354 controls from the Breast Cancer
                      Association Consortium. Interactions were evaluated using
                      standard logistic regression, and a newly developed
                      case-only method, for breast cancer risk overall and by
                      estrogen receptor status. After accounting for multiple
                      testing, we did not find evidence that per-standard
                      deviation PRS313 odds ratio differed across strata defined
                      by individual risk factors. Goodness-of-fit tests did not
                      reject the assumption of a multiplicative model between
                      PRS313 and each risk factor. Variation in projected absolute
                      lifetime risk of breast cancer associated with classical
                      risk factors was greater for women with higher genetic risk
                      (PRS313 and family history), and on average $17.5\%$ higher
                      in the highest vs lowest deciles of genetic risk. These
                      findings have implications for risk prevention for women at
                      increased risk of breast cancer.},
      cin          = {C020 / C071 / C070 / C120 / HD01 / C055 / B072 / B070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C071-20160331 /
                      I:(DE-He78)C070-20160331 / I:(DE-He78)C120-20160331 /
                      I:(DE-He78)HD01-20160331 / I:(DE-He78)C055-20160331 /
                      I:(DE-He78)B072-20160331 / I:(DE-He78)B070-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32359158},
      doi          = {10.1093/jnci/djaa056},
      url          = {https://inrepo02.dkfz.de/record/154698},
}