Journal Article

DKFZ-2020-00956

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Combined associations of a polygenic risk score and classical risk factors with breast cancer risk.

Kapoor, P. M. (First author)DKFZ* ; Mavaddat, N. ; Choudhury, P. P. ; Wilcox, A. N. ; Lindström, S. ; Behrens, S.DKFZ* ; Michailidou, K. ; Dennis, J. ; Bolla, M. K. ; Wang, Q. ; Jung, A.DKFZ* ; Abu-Ful, Z. ; Ahearn, T. ; Andrulis, I. L. ; Anton-Culver, H. ; Arndt, V.DKFZ* ; Aronson, K. J. ; Auer, P. L. ; Freeman, L. E. B. ; Becher, H. ; Beckmann, M. W. ; Beeghly-Fadiel, A. ; Benitez, J. ; Bernstein, L. ; Bojesen, S. E. ; Brauch, H.DKFZ* ; Brenner, H.DKFZ* ; Brüning, T. ; Cai, Q. ; Campa, D. ; Canzian, F.DKFZ* ; Carracedo, A. ; Carter, B. D. ; Castelao, J. E. ; Chanock, S. J. ; Chatterjee, N. ; Chenevix-Trench, G. ; Clarke, C. L. ; Couch, F. J. ; Cox, A. ; Cross, S. S. ; Czene, K. ; Dai, J. Y. ; Earp, H. S. ; Ekici, A. B. ; Eliassen, A. H. ; Eriksson, M. ; Evans, D. G. ; Fasching, P. A. ; Figueroa, J. ; Fritschi, L. ; Gabrielson, M. ; Gago-Dominguez, M. ; Gao, C. ; Gapstur, S. M. ; Gaudet, M. M. ; Giles, G. G. ; González-Neira, A. ; Guénel, P. ; Haeberle, L. ; Haiman, C. A. ; Håkansson, N. ; Hall, P. ; Hamann, U.DKFZ* ; Hatse, S. ; Heyworth, J. ; Holleczek, B. ; Hoover, R. N. ; Hopper, J. L. ; Howell, A. ; Hunter, D. J. ; Investigators, A. (Collaboration Author) ; Investigators, k. (Collaboration Author) ; John, E. M. ; Jones, M. E. ; Kaaks, R.DKFZ* ; Keeman, R. ; Kitahara, C. M. ; Ko, Y.-D. ; Koutros, S. ; Kurian, A. W. ; Lambrechts, D. ; Marchand, L. L. ; Lee, E. ; Lejbkowicz, F. ; Linet, M. ; Lissowska, J. ; Llaneza, A. ; MacInnis, R. J. ; Martinez, M. E. ; Maurer, T. ; McLean, C. ; Neuhausen, S. L. ; Newman, W. G. ; Norman, A. ; O'Brien, K. M. ; Olshan, A. F. ; Olson, J. E. ; Olsson, H. ; Orr, N. ; Perou, C. M. ; Pita, G. ; Polley, E. C. ; Prentice, R. L. ; Rennert, G. ; Rennert, H. S. ; Ruddy, K. J. ; Sandler, D. P. ; Saunders, C. ; Schoemaker, M. J. ; Schöttker, B.DKFZ* ; Schumacher, F. ; Scott, C. ; Scott, R. J. ; Shu, X.-O. ; Smeets, A. ; Southey, M. C. ; Spinelli, J. J. ; Stone, J. ; Swerdlow, A. J. ; Tamimi, R. M. ; Taylor, J. A. ; Troester, M. A. ; Vachon, C. M. ; van Veen, E. M. ; Wang, X. ; Weinberg, C. R. ; Weltens, C. ; Willett, W. ; Winham, S. J. ; Wolk, A. ; Yang, X. R. ; Zheng, W. ; Ziogas, A. ; Dunning, A. M. ; Pharoah, P. D. P. ; Schmidt, M. K. ; Kraft, P. ; Easton, D. F. ; Milne, R. L. ; García-Closas, M. ; Chang-Claude, J. (Last author)DKFZ*

2021
Oxford Univ. Press Oxford

This record in other databases:  

Please use a persistent id in citations: doi:10.1093/jnci/djaa056

Abstract: We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72,284 cases and 80,354 controls from the Breast Cancer Association Consortium. Interactions were evaluated using standard logistic regression, and a newly developed case-only method, for breast cancer risk overall and by estrogen receptor status. After accounting for multiple testing, we did not find evidence that per-standard deviation PRS313 odds ratio differed across strata defined by individual risk factors. Goodness-of-fit tests did not reject the assumption of a multiplicative model between PRS313 and each risk factor. Variation in projected absolute lifetime risk of breast cancer associated with classical risk factors was greater for women with higher genetic risk (PRS313 and family history), and on average 17.5% higher in the highest vs lowest deciles of genetic risk. These findings have implications for risk prevention for women at increased risk of breast cancer.

Note: Volume 113, Issue 3, March 2021, Pages 329–337

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C071 Cancer Survivorship (C071)
3. C070 Klinische Epidemiologie und Alternf. (C070)
4. Präventive Onkologie (C120)
5. DKTK HD zentral (HD01)
6. C055 Genomische Epidemiologie (C055)
7. B072 Molekulargenetik des Mammakarzinoms (B072)
8. B070 Funktionelle Genomanalyse (B070)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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