%0 Journal Article
%A Pletsch-Borba, Laura
%A Grafetstätter, Mirja
%A Hüsing, Anika
%A Johnson, Theron
%A González Maldonado, Sandra
%A Groß, Marie-Luise
%A Kloss, Manja
%A Hoffmeister, Michael
%A Bugert, Peter
%A Kaaks, Rudolf
%A Kühn, Tilman
%T Vascular injury biomarkers and stroke risk: A population-based study.
%J Neurology
%V 94
%N 22
%@ 1526-632X
%C [S.l.]
%I Ovid
%M DKFZ-2020-00992
%P e2337-e2345
%D 2020
%Z 2020 Jun 2;94(22):e2337-e2345#EA:C020#LA:C020#
%X Because little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study.A case-cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition-Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Weighted Cox regression analyses were used to assess associations between biomarker levels and stroke risk.Median follow-up in the subcohort and among cases was 9.8 (range, 0.1-12.5) years and 6.2 (range, 0.01-12.1) years, respectively. ICAM3 levels were associated with increased risk of incident stroke after multivariable adjustment (hazard ratio, highest vs lowest quartile: 1.64 [95
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32371447
%R 10.1212/WNL.0000000000009391
%U https://inrepo02.dkfz.de/record/154738