Journal Article

DKFZ-2020-00992

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Vascular injury biomarkers and stroke risk: A population-based study.

Pletsch-Borba, L. (First author)DKFZ* ; Grafetstätter, M.DKFZ* ; Hüsing, A.DKFZ* ; Johnson, T.DKFZ* ; González Maldonado, S.DKFZ* ; Groß, M.-L.DKFZ* ; Kloss, M.DKFZ* ; Hoffmeister, M.DKFZ* ; Bugert, P.DKFZ* ; Kaaks, R.DKFZ* ; Kühn, T. (Last author)DKFZ*

2020
Ovid [S.l.]

This record in other databases:  

Please use a persistent id in citations: doi:10.1212/WNL.0000000000009391

Abstract: Because little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study.A case-cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition-Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Weighted Cox regression analyses were used to assess associations between biomarker levels and stroke risk.Median follow-up in the subcohort and among cases was 9.8 (range, 0.1-12.5) years and 6.2 (range, 0.01-12.1) years, respectively. ICAM3 levels were associated with increased risk of incident stroke after multivariable adjustment (hazard ratio, highest vs lowest quartile: 1.64 [95% confidence interval, 1.15-2.32]; plinear trend < 0.001). This association was more apparent for ischemic (1.65 [1.12-2.45]; plinear trend < 0.01) than for hemorrhagic stroke (1.29 [0.60-2.78]; plinear trend = 0.3). We further observed a borderline significant trend for a positive association between sTM and overall stroke risk (1.47 [0.99-2.19]; plinear trend = 0.05).In this population-based study, circulating levels of ICAM3, an adhesion molecule shed by leukocytes, were associated with increased risk of incident stroke. Further mechanistic studies are needed to elucidate the pathophysiology underlying this association.This study provides Class II evidence that plasma levels of ICAM3 are associated with increased stroke risk.

Note: 2020 Jun 2;94(22):e2337-e2345#EA:C020#LA:C020#

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)
2. C070 Klinische Epidemiologie und Alternf. (C070)

Research Program(s):

1. 323 - Metabolic Dysfunction as Risk Factor (POF3-323) (POF3-323)

Appears in the scientific report 2020

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Database coverage:
; Allianz-Lizenz ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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