TY  - JOUR
AU  - Pletsch-Borba, Laura
AU  - Grafetstätter, Mirja
AU  - Hüsing, Anika
AU  - Johnson, Theron
AU  - González Maldonado, Sandra
AU  - Groß, Marie-Luise
AU  - Kloss, Manja
AU  - Hoffmeister, Michael
AU  - Bugert, Peter
AU  - Kaaks, Rudolf
AU  - Kühn, Tilman
TI  - Vascular injury biomarkers and stroke risk: A population-based study.
JO  - Neurology
VL  - 94
IS  - 22
SN  - 1526-632X
CY  - [S.l.]
PB  - Ovid
M1  - DKFZ-2020-00992
SP  - e2337-e2345
PY  - 2020
N1  - 2020 Jun 2;94(22):e2337-e2345#EA:C020#LA:C020#
AB  - Because little is known about associations between biomarkers of vascular injury and stroke risk, we evaluated associations between plasma concentrations of 6 novel biomarkers of vascular injury and stroke risk in a population-based study.A case-cohort subset of EPIC-Heidelberg (European Prospective Investigation for Cancer and Nutrition-Heidelberg) including incident stroke cases (n = 335) and a random subcohort (n = 2,418) was selected. Concentrations of intercellular adhesion molecule 3 (ICAM3), soluble E-selectin and P-selectin, soluble thrombomodulin (sTM), thrombopoietin, and glycoprotein IIb/IIIa were measured in baseline plasma samples. Weighted Cox regression analyses were used to assess associations between biomarker levels and stroke risk.Median follow-up in the subcohort and among cases was 9.8 (range, 0.1-12.5) years and 6.2 (range, 0.01-12.1) years, respectively. ICAM3 levels were associated with increased risk of incident stroke after multivariable adjustment (hazard ratio, highest vs lowest quartile: 1.64 [95
LB  - PUB:(DE-HGF)16
C6  - pmid:32371447
DO  - DOI:10.1212/WNL.0000000000009391
UR  - https://inrepo02.dkfz.de/record/154738
ER  -