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@ARTICLE{PletschBorba:154738,
      author       = {L. Pletsch-Borba$^*$ and M. Grafetstätter$^*$ and A.
                      Hüsing$^*$ and T. Johnson$^*$ and S. González
                      Maldonado$^*$ and M.-L. Groß$^*$ and M. Kloss$^*$ and M.
                      Hoffmeister$^*$ and P. Bugert$^*$ and R. Kaaks$^*$ and T.
                      Kühn$^*$},
      title        = {{V}ascular injury biomarkers and stroke risk: {A}
                      population-based study.},
      journal      = {Neurology},
      volume       = {94},
      number       = {22},
      issn         = {1526-632X},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {DKFZ-2020-00992},
      pages        = {e2337-e2345},
      year         = {2020},
      note         = {2020 Jun 2;94(22):e2337-e2345#EA:C020#LA:C020#},
      abstract     = {Because little is known about associations between
                      biomarkers of vascular injury and stroke risk, we evaluated
                      associations between plasma concentrations of 6 novel
                      biomarkers of vascular injury and stroke risk in a
                      population-based study.A case-cohort subset of
                      EPIC-Heidelberg (European Prospective Investigation for
                      Cancer and Nutrition-Heidelberg) including incident stroke
                      cases (n = 335) and a random subcohort (n = 2,418) was
                      selected. Concentrations of intercellular adhesion molecule
                      3 (ICAM3), soluble E-selectin and P-selectin, soluble
                      thrombomodulin (sTM), thrombopoietin, and glycoprotein
                      IIb/IIIa were measured in baseline plasma samples. Weighted
                      Cox regression analyses were used to assess associations
                      between biomarker levels and stroke risk.Median follow-up in
                      the subcohort and among cases was 9.8 (range, 0.1-12.5)
                      years and 6.2 (range, 0.01-12.1) years, respectively. ICAM3
                      levels were associated with increased risk of incident
                      stroke after multivariable adjustment (hazard ratio, highest
                      vs lowest quartile: 1.64 $[95\%$ confidence interval,
                      1.15-2.32]; plinear trend < 0.001). This association was
                      more apparent for ischemic (1.65 [1.12-2.45]; plinear trend
                      < 0.01) than for hemorrhagic stroke (1.29 [0.60-2.78];
                      plinear trend = 0.3). We further observed a borderline
                      significant trend for a positive association between sTM and
                      overall stroke risk (1.47 [0.99-2.19]; plinear trend =
                      0.05).In this population-based study, circulating levels of
                      ICAM3, an adhesion molecule shed by leukocytes, were
                      associated with increased risk of incident stroke. Further
                      mechanistic studies are needed to elucidate the
                      pathophysiology underlying this association.This study
                      provides Class II evidence that plasma levels of ICAM3 are
                      associated with increased stroke risk.},
      cin          = {C020 / C070},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331 / I:(DE-He78)C070-20160331},
      pnm          = {323 - Metabolic Dysfunction as Risk Factor (POF3-323)},
      pid          = {G:(DE-HGF)POF3-323},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32371447},
      doi          = {10.1212/WNL.0000000000009391},
      url          = {https://inrepo02.dkfz.de/record/154738},
}