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| Home > Publications database > Contrast agent accumulation patterns in chronic interstitial lung disease using 5d MRI. |
| Journal Article | DKFZ-2020-01112 |
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2020
Wiley
Bognor Regis
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Please use a persistent id in citations: doi:10.1259/bjr.20190121
Abstract: To analyse delayed contrast dynamics of fibrotic lesions in interstitial lung disease (ILD) using 5D MRI and to correlate contrast dynamics with disease severity.20 patients (mean age: 71 years; M:F, 13:7), with chronic fibrosing ILD: n = 12 idiopathic pulmonary fibrosis (IPF) and n = 8 non-IPF, underwent thin-section multislice CT as part of the standard diagnostic workup and additionally MRI of the lung. Two minutes after contrast injection, a radial gradient echo sequence with golden-angle spacing was acquired during 5 min of free-breathing, followed by 5D image reconstruction. Disease was categorized as severe or non-severe according to CT morphological regional severity. For each patient 10 lesions were analysed.IPF lesions showed later peak enhancement compared to non-IPF (severe: p = 0.01, non-severe: p = 0.003). Severe lesions showed later peak enhancement compared to non-severe lesions, in non-IPF (p = 0.04), but not in IPF (p = 0.35). There was a tendency towards higher accumulation and washout rates in IPF compared to non-IPF in non-severe disease. Severe lesions had lower wash-out rate than non-severe ones in both IPF (p = 0.003) and non-IPF (p = 0.005). Continuous contrast agent accumulation, without wash-out, was found only in IPF lesions.Contrast agent dynamics are influenced by type and severity of pulmonary fibrosis, which might enable a more thorough characterization of disease burden. The regional impairment is of particular interest in the context of antifibrotic treatments and was characterized using a non-invasive, non-irradiating, free-breathing method.Delayed contrast enhancement patterns allow the assessment of regional lung impairment which could represent different disease stages or phenotypes in ILD.
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