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@ARTICLE{Jung:156848,
      author       = {A. Y. Jung$^*$ and A. Hüsing$^*$ and S. Behrens$^*$ and J.
                      Krzykalla$^*$ and N. Obi and H. Becher and J.
                      Chang-Claude$^*$},
      title        = {{P}ostdiagnosis weight change is associated with poorer
                      survival in breast cancer survivors: a prospective
                      population-based patient cohort study.},
      journal      = {International journal of cancer},
      volume       = {148},
      number       = {1},
      issn         = {1097-0215},
      address      = {Bognor Regis},
      publisher    = {Wiley-Liss},
      reportid     = {DKFZ-2020-01165},
      pages        = {18-27},
      year         = {2021},
      note         = {#EA:C020#LA:C020#2021 Jan 1;148(1):18-27},
      abstract     = {More women are surviving after breast cancer due to early
                      detection and modern treatment strategies. Body weight also
                      influences survival. We aimed to characterize associations
                      between postdiagnosis weight change and prognosis in
                      postmenopausal long-term breast cancer survivors. We used
                      data from a prospective population-based patient cohort
                      study (MARIE) conducted in two geographical regions of
                      Germany. Breast cancer patients diagnosed 50-74 years of
                      age with an incident invasive breast cancer or in situ
                      tumour were recruited in 2002-2005 and followed up until
                      June 2015. Baseline weight was ascertained at an in-person
                      interview at recruitment and follow-up weight was
                      ascertained by telephone interview in 2009. Delayed entry
                      Cox proportional hazards regression was used to assess
                      associations between relative weight change and all-cause
                      mortality, breast cancer mortality, and recurrence-free
                      survival. In total, 2216 patients were included. Compared to
                      weight maintenance (within $5\%),$ weight loss $>10\%$
                      increased risk of all-cause mortality (HR 2.50, $95\%CI$
                      1.61, 3.88), breast cancer mortality (HR 3.07, $95\%CI$
                      1.69, 5.60), and less so of recurrence-free survival (HR
                      1.43, $95\%CI$ 0.87, 2.36). Large weight gain of $>10\%$
                      also increased all-cause mortality (HR 1.64, $95\%CI$ 1.02,
                      2.62) and breast cancer mortality (HR 2.25, $95\%CI$ 1.25,
                      4.04). Weight maintenance for up to 5 years in long-term
                      breast cancer survivors may help improve survival and
                      prognosis. Postdiagnosis fluctuations in body weight of
                      greater than $10\%$ may lead to increased mortality.
                      Survivors should be recommended to avoid large deviations in
                      body weight from diagnosis onwards in order to maintain
                      health and prolong life. This article is protected by
                      copyright. All rights reserved.},
      cin          = {C020},
      ddc          = {610},
      cid          = {I:(DE-He78)C020-20160331},
      pnm          = {313 - Krebsrisikofaktoren und Prävention (POF4-313)},
      pid          = {G:(DE-HGF)POF4-313},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32621760},
      doi          = {10.1002/ijc.33181},
      url          = {https://inrepo02.dkfz.de/record/156848},
}