Journal Article

DKFZ-2020-01165

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Postdiagnosis weight change is associated with poorer survival in breast cancer survivors: a prospective population-based patient cohort study.

Jung, A. Y. (First author)DKFZ* ; Hüsing, A.DKFZ* ; Behrens, S.DKFZ* ; Krzykalla, J.DKFZ* ; Obi, N. ; Becher, H. ; Chang-Claude, J. (Last author)DKFZ*

2021
Wiley-Liss Bognor Regis

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Please use a persistent id in citations: doi:10.1002/ijc.33181

Abstract: More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective population-based patient cohort study (MARIE) conducted in two geographical regions of Germany. Breast cancer patients diagnosed 50-74 years of age with an incident invasive breast cancer or in situ tumour were recruited in 2002-2005 and followed up until June 2015. Baseline weight was ascertained at an in-person interview at recruitment and follow-up weight was ascertained by telephone interview in 2009. Delayed entry Cox proportional hazards regression was used to assess associations between relative weight change and all-cause mortality, breast cancer mortality, and recurrence-free survival. In total, 2216 patients were included. Compared to weight maintenance (within 5%), weight loss >10% increased risk of all-cause mortality (HR 2.50, 95%CI 1.61, 3.88), breast cancer mortality (HR 3.07, 95%CI 1.69, 5.60), and less so of recurrence-free survival (HR 1.43, 95%CI 0.87, 2.36). Large weight gain of >10% also increased all-cause mortality (HR 1.64, 95%CI 1.02, 2.62) and breast cancer mortality (HR 2.25, 95%CI 1.25, 4.04). Weight maintenance for up to 5 years in long-term breast cancer survivors may help improve survival and prognosis. Postdiagnosis fluctuations in body weight of greater than 10% may lead to increased mortality. Survivors should be recommended to avoid large deviations in body weight from diagnosis onwards in order to maintain health and prolong life. This article is protected by copyright. All rights reserved.

Note: #EA:C020#LA:C020#2021 Jan 1;148(1):18-27

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Contributing Institute(s):

1. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Krebsrisikofaktoren und Prävention (POF4-313) (POF4-313)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; Essential Science Indicators ; IF < 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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