TY  - JOUR
AU  - Mein, Stewart
AU  - Klein, Carmen
AU  - Kopp, Benedikt
AU  - Magro, Giuseppe
AU  - Harrabi, Semi
AU  - Karger, Christian P
AU  - Haberer, Thomas
AU  - Debus, Jürgen
AU  - Abdollahi, Amir
AU  - Dokic, Ivana
AU  - Mairani, Andrea
TI  - Assessment of RBE-weighted dose models for carbon ion therapy towards modernization of clinical practice at HIT: in vitro, in vivo and in patients.
JO  - International journal of radiation oncology, biology, physics
VL  - 108
IS  - 3
SN  - 0360-3016
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DKFZ-2020-01230
SP  - 779-791
PY  - 2020
N1  - 2020 Nov 1;108(3):779-791#EA:E210#LA:E210#
AB  - Present-day treatment planning in carbon ion therapy is conducted with assumptions for a limited number of tissue types and models for effective dose. Here, we comprehensively assess relative biological effectiveness (RBE) in carbon ion therapy and associated models towards the modernization of current clinical practice in effective dose calculation.Using two human (A549, H460) and two mouse (B16, Renca) tumor cell lines, clonogenic cell survival assay was performed for examination of changes in RBE along the full range of clinical-like spread-out Bragg peak (SOBP) fields. Prediction power of the local effect model (LEM1 and LEM4) and the modified microdosimetric kinetic model (mMKM) was assessed. Experimentation and analysis were carried out in the frame of a multi-dimensional endpoint study for clinically relevant ranges of physical dose (D), dose-averaged linear energy transfer (LETd) and base-line photon radio-sensitivity (α/β)x. Additionally, predictions were compared against previously reported RBE measurements in vivo and surveyed in patient cases.RBE model prediction performance varied amongst the investigated perspectives, with mMKM prediction exhibiting superior agreement with measurements both in vitro and in vivo across the three investigated endpoints. LEM1 and LEM4 performed their best in the highest LET conditions but yielded over- and underestimations in low/mid-range LET conditions, respectively, as demonstrated by comparison with measurements. Additionally, the analysis of patient treatment plans revealed substantial variability across the investigated models (±20-30
LB  - PUB:(DE-HGF)16
C6  - pmid:32504659
DO  - DOI:10.1016/j.ijrobp.2020.05.041
UR  - https://inrepo02.dkfz.de/record/156923
ER  -