guest ::
| Home > Publications database > Assessment of RBE-weighted dose models for carbon ion therapy towards modernization of clinical practice at HIT: in vitro, in vivo and in patients. |
| Home > Publications database > Assessment of RBE-weighted dose models for carbon ion therapy towards modernization of clinical practice at HIT: in vitro, in vivo and in patients. |
| Journal Article | DKFZ-2020-01230 |
; ; ; ; ; ; ; ; ; ;
2020
Elsevier Science
Amsterdam [u.a.]
This record in other databases: 
Please use a persistent id in citations: doi:10.1016/j.ijrobp.2020.05.041
Abstract: Present-day treatment planning in carbon ion therapy is conducted with assumptions for a limited number of tissue types and models for effective dose. Here, we comprehensively assess relative biological effectiveness (RBE) in carbon ion therapy and associated models towards the modernization of current clinical practice in effective dose calculation.Using two human (A549, H460) and two mouse (B16, Renca) tumor cell lines, clonogenic cell survival assay was performed for examination of changes in RBE along the full range of clinical-like spread-out Bragg peak (SOBP) fields. Prediction power of the local effect model (LEM1 and LEM4) and the modified microdosimetric kinetic model (mMKM) was assessed. Experimentation and analysis were carried out in the frame of a multi-dimensional endpoint study for clinically relevant ranges of physical dose (D), dose-averaged linear energy transfer (LETd) and base-line photon radio-sensitivity (α/β)x. Additionally, predictions were compared against previously reported RBE measurements in vivo and surveyed in patient cases.RBE model prediction performance varied amongst the investigated perspectives, with mMKM prediction exhibiting superior agreement with measurements both in vitro and in vivo across the three investigated endpoints. LEM1 and LEM4 performed their best in the highest LET conditions but yielded over- and underestimations in low/mid-range LET conditions, respectively, as demonstrated by comparison with measurements. Additionally, the analysis of patient treatment plans revealed substantial variability across the investigated models (±20-30% uncertainty), largely dependent on the selected model and absolute values for input tissue parameters ax and βx.RBE dependencies in vitro, in vivo and in silico were investigated with respect to various clinically relevant endpoints in the context of tumor-specific tissue radio-sensitivity assignment and accurate RBE modeling. Discovered model trends and performances advocate upgrading current treatment planning schemes in carbon ion therapy and call for verification via clinical outcome analysis with large patient cohorts.
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz
; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection
|
The record appears in these collections: |