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@ARTICLE{Kelleter:157013,
      author       = {L. Kelleter and R. Radogna and L. Volz$^*$ and D. Attree
                      and A. Basharina-Freshville and J. Seco$^*$ and R. Saakyan
                      and S. Jolly},
      title        = {{A} scintillator-based range telescope for particle
                      therapy.},
      journal      = {Physics in medicine and biology},
      volume       = {65},
      number       = {16},
      issn         = {1361-6560},
      address      = {Bristol},
      publisher    = {IOP Publ.},
      reportid     = {DKFZ-2020-01310},
      pages        = {165001},
      year         = {2020},
      note         = {2020 Aug 19;65(16):165001},
      abstract     = {The commissioning and operation of a particle therapy
                      centre requires an extensive set of detectors for measuring
                      various parameters of the treatment beam. Among the key
                      devices are detectors for beam range quality assurance. In
                      this work, a novel range telescope based on plastic
                      scintillator and read out by a large-scale CMOS sensor is
                      presented. The detector is made of a stack of 49 plastic
                      scintillator sheets with a thickness of 2--3~mm and an
                      active area of $100\times100$~mm$^2$, resulting in a total
                      physical stack thickness of 124.2~mm. This compact design
                      avoids optical artefacts that are common in other
                      scintillation detectors. The range of a proton beam is
                      reconstructed using a novel Bragg curve model that
                      incorporates scintillator quenching effects. Measurements to
                      characterise the performance of the detector were carried
                      out at the Heidelberger Ionenstrahl-Therapiezentrum (HIT,
                      Heidelberg, GER) and the Clatterbridge Cancer Centre (CCC,
                      Bebington, UK). The maximum difference between the measured
                      range and the reference range was found to be 0.41~mm at a
                      proton beam range of 310~mm and was dominated by detector
                      alignment uncertainties. With the new detector prototype,
                      the water-equivalent thickness of PMMA degrader blocks has
                      been reconstructed within $\pm0.1$~mm. An evaluation of the
                      radiation hardness proves that the range reconstruction
                      algorithm is robust following the deposition of 6,300~Gy
                      peak dose into the detector. Furthermore, small variations
                      in the beam spot size and transverse beam position are shown
                      to have a negligible effect on the range reconstruction
                      accuracy. The potential for range measurements of ion beams
                      is also investigated.},
      cin          = {E041},
      ddc          = {530},
      cid          = {I:(DE-He78)E041-20160331},
      pnm          = {315 - Imaging and radiooncology (POF3-315)},
      pid          = {G:(DE-HGF)POF3-315},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32422621},
      doi          = {10.1088/1361-6560/ab9415},
      url          = {https://inrepo02.dkfz.de/record/157013},
}