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000157047 041__ $$aeng
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000157047 1001_ $$00000-0002-8443-6754$$aYuan, Fangcheng$$b0
000157047 245__ $$aGenome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk.
000157047 260__ $$aPhiladelphia, Pa.$$bAACR$$c2020
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000157047 500__ $$a2020 Sep 15;80(18):4004-4013
000157047 520__ $$aRegistry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (+/- 500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn's disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at P-values < 0.05 (0.0040, 0.0057, 0.011, and 3.4 × 10-6, respectively). After excluding the 20 PDAC susceptibility regions (+/- 500 kb) previously identified by GWAS, the genomic regions for ulcerative colitis, Crohn's disease, and inflammatory bowel disease remained associated with PDAC (P-values = 0.0029, 0.0057, and 0.0098, respectively). Genomic regions for celiac disease (P-value = 0.22) and primary sclerosing cholangitis (P-value = 0.078) were not associated with PDAC. Our results support the hypothesis that genomic regions surrounding variants associated with inflammatory intestinal diseases, particularly, ulcerative colitis, Crohn's disease, inflammatory bowel disease, and chronic pancreatitis are associated with PDAC.
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000157047 7001_ $$00000-0002-2178-3564$$aWalsh, Naomi$$b2
000157047 7001_ $$aZhang, Han$$b3
000157047 7001_ $$00000-0003-3676-8954$$aPlatz, Elizabeth A$$b4
000157047 7001_ $$aWheeler, William$$b5
000157047 7001_ $$aSong, Lei$$b6
000157047 7001_ $$00000-0002-7775-8085$$aArslan, Alan A$$b7
000157047 7001_ $$aBeane Freeman, Laura E$$b8
000157047 7001_ $$aBracci, Paige$$b9
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000157047 7001_ $$aDu, Mengmeng$$b11
000157047 7001_ $$aGallinger, Steven$$b12
000157047 7001_ $$00000-0003-4946-9099$$aGiles, Graham G$$b13
000157047 7001_ $$aGoodman, Phyllis J$$b14
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000157047 7001_ $$aLe Marchand, Loic$$b16
000157047 7001_ $$aNeale, Rachel E$$b17
000157047 7001_ $$aRosendahl, Jonas$$b18
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000157047 7001_ $$aShu, Xiao-Ou$$b20
000157047 7001_ $$aVisvanathan, Kala$$b21
000157047 7001_ $$aWhite, Emily$$b22
000157047 7001_ $$aZheng, Wei$$b23
000157047 7001_ $$aAlbanes, Demetrius$$b24
000157047 7001_ $$aAmiano, Pilar$$b25
000157047 7001_ $$aAndreotti, Gabriella$$b26
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000157047 7001_ $$aReal, Francisco X$$b54
000157047 7001_ $$aRothman, Nathaniel$$b55
000157047 7001_ $$aSesso, Howard D$$b56
000157047 7001_ $$aSilverman, Debra T$$b57
000157047 7001_ $$aThompson, Ian M$$b58
000157047 7001_ $$00000-0003-3096-9595$$aWactawski-Wende, Jean$$b59
000157047 7001_ $$aWang, Xiaoliang$$b60
000157047 7001_ $$aWentzensen, Nicolas$$b61
000157047 7001_ $$aWilkens, Lynne R$$b62
000157047 7001_ $$00000-0003-3950-4815$$aYu, Herbert$$b63
000157047 7001_ $$aZeleniuch-Jacquotte, Anne$$b64
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000157047 7001_ $$00000-0001-5256-0163$$aDuell, Eric J$$b66
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000157047 7001_ $$00000-0002-7542-0662$$aLi, Donghui$$b68
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000157047 7001_ $$aYu, Kai$$b72
000157047 7001_ $$00000-0003-2737-8399$$aKlein, Alison P$$b73
000157047 7001_ $$00000-0003-3698-7006$$aStolzenberg-Solomon, Rachael$$b74
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