Journal Article

DKFZ-2020-01338

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk.

Yuan, F. ; Hung, R. J. ; Walsh, N. ; Zhang, H. ; Platz, E. A. ; Wheeler, W. ; Song, L. ; Arslan, A. A. ; Beane Freeman, L. E. ; Bracci, P. ; Canzian, F.DKFZ* ; Du, M. ; Gallinger, S. ; Giles, G. G. ; Goodman, P. J. ; Kooperberg, C. ; Le Marchand, L. ; Neale, R. E. ; Rosendahl, J. ; Scelo, G. ; Shu, X.-O. ; Visvanathan, K. ; White, E. ; Zheng, W. ; Albanes, D. ; Amiano, P. ; Andreotti, G. ; Babic, A. ; Bamlet, W. R. ; Berndt, S. I. ; Brennan, P. ; Bueno-de-Mesquita, B. ; Buring, J. E. ; Campbell, P. T. ; Chanock, S. J. ; Fuchs, C. S. ; Gaziano, J. M. ; Goggins, M. G. ; Hackert, T. ; Hartge, P. ; Hassan, M. M. ; Holly, E. A. ; Hoover, R. N. ; Katzke, V.DKFZ* ; Kirsten, H. ; Kurtz, R. C. ; Lee, I.-M. ; Malats, N. ; Milne, R. ; Murphy, N. ; Ng, K. ; Oberg, A. L. ; Porta, M. ; Rabe, K. G. ; Real, F. X. ; Rothman, N. ; Sesso, H. D. ; Silverman, D. T. ; Thompson, I. M. ; Wactawski-Wende, J. ; Wang, X. ; Wentzensen, N. ; Wilkens, L. R. ; Yu, H. ; Zeleniuch-Jacquotte, A. ; Shi, J. ; Duell, E. J. ; Amundadottir, L. T. ; Li, D. ; Petersen, G. M. ; Wolpin, B. M. ; Risch, H. A. ; Yu, K. ; Klein, A. P. ; Stolzenberg-Solomon, R.

2020
AACR Philadelphia, Pa.

This record in other databases:  

Please use a persistent id in citations: doi:10.1158/0008-5472.CAN-20-0447

Abstract: Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (+/- 500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn's disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at P-values < 0.05 (0.0040, 0.0057, 0.011, and 3.4 × 10-6, respectively). After excluding the 20 PDAC susceptibility regions (+/- 500 kb) previously identified by GWAS, the genomic regions for ulcerative colitis, Crohn's disease, and inflammatory bowel disease remained associated with PDAC (P-values = 0.0029, 0.0057, and 0.0098, respectively). Genomic regions for celiac disease (P-value = 0.22) and primary sclerosing cholangitis (P-value = 0.078) were not associated with PDAC. Our results support the hypothesis that genomic regions surrounding variants associated with inflammatory intestinal diseases, particularly, ulcerative colitis, Crohn's disease, inflammatory bowel disease, and chronic pancreatitis are associated with PDAC.

Note: 2020 Sep 15;80(18):4004-4013

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Contributing Institute(s):

1. C055 Genomische Epidemiologie (C055)
2. C020 Epidemiologie von Krebs (C020)

Research Program(s):

1. 313 - Cancer risk factors and prevention (POF3-313) (POF3-313)

Appears in the scientific report 2020

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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