TY  - JOUR
AU  - Yuan, Fangcheng
AU  - Hung, Rayjean J
AU  - Walsh, Naomi
AU  - Zhang, Han
AU  - Platz, Elizabeth A
AU  - Wheeler, William
AU  - Song, Lei
AU  - Arslan, Alan A
AU  - Beane Freeman, Laura E
AU  - Bracci, Paige
AU  - Canzian, Federico
AU  - Du, Mengmeng
AU  - Gallinger, Steven
AU  - Giles, Graham G
AU  - Goodman, Phyllis J
AU  - Kooperberg, Charles
AU  - Le Marchand, Loic
AU  - Neale, Rachel E
AU  - Rosendahl, Jonas
AU  - Scelo, Ghislaine
AU  - Shu, Xiao-Ou
AU  - Visvanathan, Kala
AU  - White, Emily
AU  - Zheng, Wei
AU  - Albanes, Demetrius
AU  - Amiano, Pilar
AU  - Andreotti, Gabriella
AU  - Babic, Ana
AU  - Bamlet, William R
AU  - Berndt, Sonja I
AU  - Brennan, Paul
AU  - Bueno-de-Mesquita, Bas
AU  - Buring, Julie E
AU  - Campbell, Peter T
AU  - Chanock, Stephen J
AU  - Fuchs, Charles S
AU  - Gaziano, J Michael
AU  - Goggins, Michael G
AU  - Hackert, Thilo
AU  - Hartge, Patricia
AU  - Hassan, Manal M
AU  - Holly, Elizabeth A
AU  - Hoover, Robert N
AU  - Katzke, Verena
AU  - Kirsten, Holger
AU  - Kurtz, Robert C
AU  - Lee, I-Min
AU  - Malats, Nuria
AU  - Milne, Roger
AU  - Murphy, Neil
AU  - Ng, Kimmie
AU  - Oberg, Ann L
AU  - Porta, Miquel
AU  - Rabe, Kari G
AU  - Real, Francisco X
AU  - Rothman, Nathaniel
AU  - Sesso, Howard D
AU  - Silverman, Debra T
AU  - Thompson, Ian M
AU  - Wactawski-Wende, Jean
AU  - Wang, Xiaoliang
AU  - Wentzensen, Nicolas
AU  - Wilkens, Lynne R
AU  - Yu, Herbert
AU  - Zeleniuch-Jacquotte, Anne
AU  - Shi, Jianxin
AU  - Duell, Eric J
AU  - Amundadottir, Laufey T
AU  - Li, Donghui
AU  - Petersen, Gloria M
AU  - Wolpin, Brian M
AU  - Risch, Harvey A
AU  - Yu, Kai
AU  - Klein, Alison P
AU  - Stolzenberg-Solomon, Rachael
TI  - Genome-wide association study data reveal genetic susceptibility to chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma risk.
JO  - Cancer research
VL  - 80
IS  - 18
SN  - 1538-7445
CY  - Philadelphia, Pa.
PB  - AACR
M1  - DKFZ-2020-01338
SP  - 4004-4013
PY  - 2020
N1  - 2020 Sep 15;80(18):4004-4013
AB  - Registry-based epidemiologic studies suggest associations between chronic inflammatory intestinal diseases and pancreatic ductal adenocarcinoma (PDAC). As genetic susceptibility contributes to a large proportion of chronic inflammatory intestinal diseases, we hypothesize that the genomic regions surrounding established genome-wide associated variants for these chronic inflammatory diseases are associated with PDAC. We examined the association between PDAC and genomic regions (+/- 500 kb) surrounding established common susceptibility variants for ulcerative colitis, Crohn's disease, inflammatory bowel disease, celiac disease, chronic pancreatitis, and primary sclerosing cholangitis. We analyzed summary statistics from genome-wide association studies data for 8,384 cases and 11,955 controls of European descent from two large consortium studies using the summary data-based adaptive rank truncated product method to examine the overall association of combined genomic regions for each inflammatory disease group. Combined genomic susceptibility regions for ulcerative colitis, Crohn's disease, inflammatory bowel disease, and chronic pancreatitis were associated with PDAC at P-values < 0.05 (0.0040, 0.0057, 0.011, and 3.4 × 10-6, respectively). After excluding the 20 PDAC susceptibility regions (+/- 500 kb) previously identified by GWAS, the genomic regions for ulcerative colitis, Crohn's disease, and inflammatory bowel disease remained associated with PDAC (P-values = 0.0029, 0.0057, and 0.0098, respectively). Genomic regions for celiac disease (P-value = 0.22) and primary sclerosing cholangitis (P-value = 0.078) were not associated with PDAC. Our results support the hypothesis that genomic regions surrounding variants associated with inflammatory intestinal diseases, particularly, ulcerative colitis, Crohn's disease, inflammatory bowel disease, and chronic pancreatitis are associated with PDAC.
LB  - PUB:(DE-HGF)16
C6  - pmid:32641412
DO  - DOI:10.1158/0008-5472.CAN-20-0447
UR  - https://inrepo02.dkfz.de/record/157047
ER  -