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000157096 1001_ $$aDemaria, Maria C$$b0
000157096 245__ $$aTetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression.
000157096 260__ $$aSt. Louis$$bElsevier$$c2020
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000157096 520__ $$aTetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation. Lymph nodes of Cd53-/- mice were smaller than those of wild-type mice due to a marked reduction in B cells and a 50% decrease in T cells. This reduced cellularity reflected an inability of Cd53-/- B and T cells to efficiently home to lymph nodes, due to the near absence of L-selectin from Cd53-/- B cells and reduced stability of L-selectin on Cd53-/- T cells. Further analyses, including on human lymphocytes, showed that CD53 stabilizes L-selectin surface expression and may restrain L-selectin shedding via both ADAM17-dependent and ADAM17-independent mechanisms. The disruption in lymphocyte recirculation in Cd53-/- mice led to impaired immune responses dependent on antigen delivery to lymph nodes. Together these findings demonstrate an essential role for CD53 in lymphocyte trafficking and immunity.
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000157096 7001_ $$aYeung, Louisa$$b1
000157096 7001_ $$aPeeters, Rens$$b2
000157096 7001_ $$aWee, Janet L$$b3
000157096 7001_ $$aMihaljcic, Masa$$b4
000157096 7001_ $$aJones, Eleanor L$$b5
000157096 7001_ $$aNasa, Zeyad$$b6
000157096 7001_ $$aAlderuccio, Frank$$b7
000157096 7001_ $$aHall, Pamela$$b8
000157096 7001_ $$aSmith, Brodie C$$b9
000157096 7001_ $$aBinger, Katrina J$$b10
000157096 7001_ $$0P:(DE-HGF)0$$aHammerling, Gunther$$b11
000157096 7001_ $$aKwok, Hang Fai$$b12
000157096 7001_ $$aNewman, Andrew$$b13
000157096 7001_ $$aAger, Ann$$b14
000157096 7001_ $$avan Spriel, Annemiek$$b15
000157096 7001_ $$aHickey, Michael J$$b16
000157096 7001_ $$aWright, Mark D$$b17
000157096 773__ $$0PERI:(DE-600)2927064-9$$a10.1016/j.isci.2020.101104$$gVol. 23, no. 5, p. 101104 -$$n5$$p101104 $$tiScience$$v23$$x2589-0042$$y2020
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