Journal Article

DKFZ-2020-01387

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression.

Demaria, M. C. ; Yeung, L. ; Peeters, R. ; Wee, J. L. ; Mihaljcic, M. ; Jones, E. L. ; Nasa, Z. ; Alderuccio, F. ; Hall, P. ; Smith, B. C. ; Binger, K. J. ; Hammerling, G.DKFZ* ; Kwok, H. F. ; Newman, A. ; Ager, A. ; van Spriel, A. ; Hickey, M. J. ; Wright, M. D.

2020
Elsevier St. Louis

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Please use a persistent id in citations: doi:10.1016/j.isci.2020.101104

Abstract: Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation. Lymph nodes of Cd53-/- mice were smaller than those of wild-type mice due to a marked reduction in B cells and a 50% decrease in T cells. This reduced cellularity reflected an inability of Cd53-/- B and T cells to efficiently home to lymph nodes, due to the near absence of L-selectin from Cd53-/- B cells and reduced stability of L-selectin on Cd53-/- T cells. Further analyses, including on human lymphocytes, showed that CD53 stabilizes L-selectin surface expression and may restrain L-selectin shedding via both ADAM17-dependent and ADAM17-independent mechanisms. The disruption in lymphocyte recirculation in Cd53-/- mice led to impaired immune responses dependent on antigen delivery to lymph nodes. Together these findings demonstrate an essential role for CD53 in lymphocyte trafficking and immunity.

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Contributing Institute(s):

1. D030 Immungenetik (D030)

Research Program(s):

1. 314 - Tumor immunology (POF3-314) (POF3-314)

Appears in the scientific report 2020

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