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@ARTICLE{Demaria:157096,
      author       = {M. C. Demaria and L. Yeung and R. Peeters and J. L. Wee and
                      M. Mihaljcic and E. L. Jones and Z. Nasa and F. Alderuccio
                      and P. Hall and B. C. Smith and K. J. Binger and G.
                      Hammerling$^*$ and H. F. Kwok and A. Newman and A. Ager and
                      A. van Spriel and M. J. Hickey and M. D. Wright},
      title        = {{T}etraspanin {CD}53 {P}romotes {L}ymphocyte
                      {R}ecirculation by {S}tabilizing {L}-{S}electin {S}urface
                      {E}xpression.},
      journal      = {iScience},
      volume       = {23},
      number       = {5},
      issn         = {2589-0042},
      address      = {St. Louis},
      publisher    = {Elsevier},
      reportid     = {DKFZ-2020-01387},
      pages        = {101104},
      year         = {2020},
      abstract     = {Tetraspanins regulate key processes in immune cells;
                      however, the function of the leukocyte-restricted
                      tetraspanin CD53 is unknown. Here we show that CD53 is
                      essential for lymphocyte recirculation. Lymph nodes of
                      Cd53-/- mice were smaller than those of wild-type mice due
                      to a marked reduction in B cells and a $50\%$ decrease in
                      T cells. This reduced cellularity reflected an inability of
                      Cd53-/- B and T cells to efficiently home to lymph nodes,
                      due to the near absence of L-selectin from Cd53-/- B cells
                      and reduced stability of L-selectin on Cd53-/- T cells.
                      Further analyses, including on human lymphocytes, showed
                      that CD53 stabilizes L-selectin surface expression and may
                      restrain L-selectin shedding via both ADAM17-dependent and
                      ADAM17-independent mechanisms. The disruption in lymphocyte
                      recirculation in Cd53-/- mice led to impaired immune
                      responses dependent on antigen delivery to lymph nodes.
                      Together these findings demonstrate an essential role for
                      CD53 in lymphocyte trafficking and immunity.},
      cin          = {D030},
      ddc          = {050},
      cid          = {I:(DE-He78)D030-20160331},
      pnm          = {314 - Tumor immunology (POF3-314)},
      pid          = {G:(DE-HGF)POF3-314},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32428859},
      pmc          = {pmc:PMC7232089},
      doi          = {10.1016/j.isci.2020.101104},
      url          = {https://inrepo02.dkfz.de/record/157096},
}